EIF4EBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031929Biological processTOR signaling
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0045947Biological processnegative regulation of translational initiation
GO_0017148Biological processnegative regulation of translation
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030371Molecular functiontranslation repressor activity
GO_0031369Molecular functiontranslation initiation factor binding
GO_0005515Molecular functionprotein binding
GO_0008190Molecular functioneukaryotic initiation factor 4E binding

IV. Literature review

[source]
Gene nameEIF4EBP1
Protein nameEukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Synonyms
DescriptionFUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. .

AccessionsENST00000338825.5
Q13541