Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 21 studies | 29% ± 11% | |
classical monocyte | 18 studies | 30% ± 10% | |
conventional dendritic cell | 16 studies | 29% ± 16% | |
non-classical monocyte | 16 studies | 30% ± 12% | |
monocyte | 12 studies | 24% ± 6% | |
fibroblast | 10 studies | 30% ± 16% | |
dendritic cell | 8 studies | 34% ± 18% | |
connective tissue cell | 7 studies | 33% ± 7% | |
pericyte | 7 studies | 21% ± 4% | |
endothelial cell | 7 studies | 24% ± 8% | |
myeloid cell | 7 studies | 26% ± 9% | |
basal cell | 7 studies | 24% ± 12% | |
plasmacytoid dendritic cell | 7 studies | 23% ± 6% | |
smooth muscle cell | 6 studies | 22% ± 4% | |
epithelial cell | 6 studies | 39% ± 9% | |
hematopoietic precursor cell | 5 studies | 31% ± 10% | |
natural killer cell | 5 studies | 19% ± 2% | |
goblet cell | 5 studies | 29% ± 13% | |
mesothelial cell | 5 studies | 42% ± 12% | |
abnormal cell | 5 studies | 30% ± 10% | |
alveolar macrophage | 4 studies | 28% ± 7% | |
progenitor cell | 4 studies | 21% ± 9% | |
myofibroblast cell | 4 studies | 25% ± 6% | |
erythroblast | 4 studies | 37% ± 6% | |
neuron | 4 studies | 35% ± 13% | |
ciliated cell | 4 studies | 24% ± 6% | |
pancreatic A cell | 3 studies | 38% ± 14% | |
leukocyte | 3 studies | 21% ± 5% | |
neural crest cell | 3 studies | 36% ± 3% | |
extravillous trophoblast | 3 studies | 41% ± 13% | |
common myeloid progenitor | 3 studies | 33% ± 10% | |
megakaryocyte | 3 studies | 26% ± 11% | |
intermediate monocyte | 3 studies | 38% ± 9% | |
endothelial cell of vascular tree | 3 studies | 21% ± 4% | |
granulocyte monocyte progenitor cell | 3 studies | 32% ± 6% | |
hematopoietic stem cell | 3 studies | 29% ± 7% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 53% ± 15% | |
transit amplifying cell | 3 studies | 18% ± 2% | |
CD4-positive, alpha-beta T cell | 3 studies | 23% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2103.93 | 1442 / 1445 | 100% | 305.75 | 183 / 183 |
stomach | 100% | 1659.01 | 359 / 359 | 100% | 231.85 | 285 / 286 |
intestine | 100% | 1161.70 | 966 / 966 | 99% | 237.09 | 524 / 527 |
uterus | 99% | 1024.32 | 169 / 170 | 100% | 322.29 | 458 / 459 |
ovary | 99% | 1015.04 | 178 / 180 | 100% | 243.59 | 430 / 430 |
bladder | 100% | 1684.05 | 21 / 21 | 99% | 276.53 | 497 / 504 |
skin | 99% | 2042.78 | 1786 / 1809 | 100% | 343.12 | 471 / 472 |
pancreas | 100% | 5523.17 | 328 / 328 | 97% | 162.57 | 173 / 178 |
breast | 100% | 2616.15 | 458 / 459 | 97% | 225.55 | 1079 / 1118 |
prostate | 99% | 1042.97 | 243 / 245 | 93% | 139.36 | 467 / 502 |
lung | 96% | 1304.35 | 553 / 578 | 95% | 286.37 | 1099 / 1155 |
liver | 100% | 1825.37 | 226 / 226 | 88% | 120.17 | 358 / 406 |
kidney | 96% | 879.99 | 85 / 89 | 85% | 122.13 | 770 / 901 |
adrenal gland | 84% | 595.02 | 217 / 258 | 56% | 50.57 | 129 / 230 |
eye | 0% | 0 | 0 / 0 | 100% | 187.79 | 80 / 80 |
spleen | 100% | 1133.61 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 282.90 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 529.68 | 1 / 1 |
adipose | 100% | 2616.60 | 1203 / 1204 | 0% | 0 | 0 / 0 |
brain | 14% | 80.95 | 381 / 2642 | 85% | 104.95 | 601 / 705 |
muscle | 99% | 2831.33 | 794 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 1202.58 | 1320 / 1335 | 0% | 0 | 0 / 0 |
thymus | 71% | 437.04 | 463 / 653 | 28% | 24.17 | 169 / 605 |
heart | 95% | 1087.94 | 818 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 132.26 | 27 / 29 |
peripheral blood | 92% | 1102.13 | 859 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031929 | Biological process | TOR signaling |
GO_0045931 | Biological process | positive regulation of mitotic cell cycle |
GO_0045947 | Biological process | negative regulation of translational initiation |
GO_0017148 | Biological process | negative regulation of translation |
GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0030371 | Molecular function | translation repressor activity |
GO_0031369 | Molecular function | translation initiation factor binding |
GO_0005515 | Molecular function | protein binding |
GO_0008190 | Molecular function | eukaryotic initiation factor 4E binding |
Gene name | EIF4EBP1 |
Protein name | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) |
Synonyms | |
Description | FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. . |
Accessions | ENST00000338825.5 Q13541 |