EIF2AK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019081Biological processviral translation
GO_0034644Biological processcellular response to UV
GO_0007612Biological processlearning
GO_0007616Biological processlong-term memory
GO_0051607Biological processdefense response to virus
GO_0060259Biological processregulation of feeding behavior
GO_0036492Biological processeiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO_0044828Biological processnegative regulation by host of viral genome replication
GO_0032792Biological processnegative regulation of CREB transcription factor activity
GO_0070417Biological processcellular response to cold
GO_1990625Biological processnegative regulation of cytoplasmic translational initiation in response to stress
GO_0002250Biological processadaptive immune response
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0071264Biological processpositive regulation of translational initiation in response to starvation
GO_0010998Biological processregulation of translational initiation by eIF2 alpha phosphorylation
GO_0006446Biological processregulation of translational initiation
GO_0045947Biological processnegative regulation of translational initiation
GO_0034198Biological processcellular response to amino acid starvation
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0002821Biological processpositive regulation of adaptive immune response
GO_0140469Biological processGCN2-mediated signaling
GO_1990138Biological processneuron projection extension
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0032057Biological processnegative regulation of translational initiation in response to stress
GO_0002286Biological processT cell activation involved in immune response
GO_0000077Biological processDNA damage checkpoint signaling
GO_0022626Cellular componentcytosolic ribosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004694Molecular functioneukaryotic translation initiation factor 2alpha kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0000049Molecular functiontRNA binding

IV. Literature review

[source]
Gene nameEIF2AK4
Protein nameEukaryotic translation initiation factor 2 alpha kinase 4
non-specific serine/threonine protein kinase (EC 2.7.11.1)
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)
SynonymsKIAA1338
GCN2
DescriptionFUNCTION: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability . Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion . Binds uncharged tRNAs (By similarity). Required for the translational induction of protein kinase PRKCH following amino acid starvation (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation . Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (By similarity). Plays a role in neurite outgrowth inhibition (By similarity). Plays a proapoptotic role in response to glucose deprivation (By similarity). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). .; FUNCTION: (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation . .

AccessionsH0YND8
Q9P2K8
ENST00000560648.1
ENST00000560855.5
ENST00000559624.5 [Q9P2K8-3]
H0YME5
ENST00000263791.10 [Q9P2K8-1]
ENST00000558823.1
H0YNY9