EHHADH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006635Biological processfatty acid beta-oxidation
GO_0033540Biological processfatty acid beta-oxidation using acyl-CoA oxidase
GO_0005829Cellular componentcytosol
GO_0005777Cellular componentperoxisome
GO_0005782Cellular componentperoxisomal matrix
GO_0003857Molecular function3-hydroxyacyl-CoA dehydrogenase activity
GO_0070403Molecular functionNAD+ binding
GO_0019899Molecular functionenzyme binding
GO_0016863Molecular functionintramolecular oxidoreductase activity, transposing C=C bonds
GO_0004300Molecular functionenoyl-CoA hydratase activity
GO_0004165Molecular functiondelta(3)-delta(2)-enoyl-CoA isomerase activity
GO_0005515Molecular functionprotein binding
GO_0016509Molecular functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO_0018812Molecular function3-hydroxyacyl-CoA dehydratase activity

IV. Literature review

[source]
Gene nameEHHADH
Protein namePeroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]
Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Peroxisomal bifunctional enzyme (Multifunctional enzyme 1)
SynonymsECHD
DescriptionFUNCTION: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (By similarity). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity . Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation . .

AccessionsA0PJI6
ENST00000440662.1
C9JJE0
ENST00000231887.8 [Q08426-1]
Q08426
ENST00000456310.5 [Q08426-2]