EFNA2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EFNA2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EFNA2 at tissue level.

III. Associated gene sets

GO_0048013Biological processephrin receptor signaling pathway
GO_0046849Biological processbone remodeling
GO_0030316Biological processosteoclast differentiation
GO_0021772Biological processolfactory bulb development
GO_0007267Biological processcell-cell signaling
GO_0007411Biological processaxon guidance
GO_0043204Cellular componentperikaryon
GO_0098552Cellular componentside of membrane
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0005515Molecular functionprotein binding
GO_0046875Molecular functionephrin receptor binding

IV. Literature review

[source]
Gene nameEFNA2
Protein nameEphrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L)
Ephrin-A2 [amino acids 176-213]
SynonymsLERK6
EPLG6
DescriptionFUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). .

AccessionsO43921
Q9HCB5
ENST00000215368.4