EDN2 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EDN2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	84%	438.36	206 / 245	66%	6.49	330 / 502
kidney	83%	391.73	74 / 89	65%	17.17	582 / 901
breast	53%	220.38	244 / 459	76%	16.40	850 / 1118
uterus	41%	139.09	70 / 170	72%	56.33	332 / 459
pancreas	66%	70.64	215 / 328	46%	5.23	81 / 178
lung	51%	203.90	294 / 578	57%	15.26	656 / 1155
ureter	0%	0	0 / 0	100%	54.43	1 / 1
esophagus	56%	400.73	806 / 1445	43%	11.91	78 / 183
bladder	52%	187.48	11 / 21	44%	9.67	220 / 504
tonsil	0%	0	0 / 0	96%	53.88	43 / 45
ovary	4%	3.45	8 / 180	77%	15.17	329 / 430
skin	70%	483.77	1263 / 1809	2%	0.37	8 / 472
intestine	44%	230.39	421 / 966	21%	1.57	110 / 527
stomach	39%	33.99	141 / 359	14%	1.04	41 / 286
thymus	27%	23.09	176 / 653	14%	1.15	84 / 605
liver	29%	28.48	65 / 226	9%	1.20	38 / 406
heart	26%	39.45	224 / 861	0%	0	0 / 0
blood vessel	23%	124.80	312 / 1335	0%	0	0 / 0
adipose	6%	9.04	69 / 1204	0%	0	0 / 0
peripheral blood	5%	2.66	43 / 929	0%	0	0 / 0
muscle	3%	4.89	27 / 803	0%	0	0 / 0
adrenal gland	2%	0.90	4 / 258	0%	0.03	1 / 230
brain	0%	0.15	6 / 2642	1%	0.14	8 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

III. Associated gene sets

GO_0097009	Biological process	energy homeostasis
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0001525	Biological process	angiogenesis
GO_0003100	Biological process	regulation of systemic arterial blood pressure by endothelin
GO_0042116	Biological process	macrophage activation
GO_0009932	Biological process	cell tip growth
GO_0048286	Biological process	lung alveolus development
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0003058	Biological process	hormonal regulation of the force of heart contraction
GO_0019229	Biological process	regulation of vasoconstriction
GO_0030593	Biological process	neutrophil chemotaxis
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0045987	Biological process	positive regulation of smooth muscle contraction
GO_0043542	Biological process	endothelial cell migration
GO_0001516	Biological process	prostaglandin biosynthetic process
GO_0014824	Biological process	artery smooth muscle contraction
GO_0048675	Biological process	axon extension
GO_0001659	Biological process	temperature homeostasis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0003099	Biological process	positive regulation of the force of heart contraction by chemical signal
GO_0042310	Biological process	vasoconstriction
GO_0014826	Biological process	vein smooth muscle contraction
GO_0060585	Biological process	positive regulation of prostaglandin-endoperoxide synthase activity
GO_0002690	Biological process	positive regulation of leukocyte chemotaxis
GO_0010460	Biological process	positive regulation of heart rate
GO_0048246	Biological process	macrophage chemotaxis
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0031708	Molecular function	endothelin B receptor binding
GO_0005179	Molecular function	hormone activity

Gene name	EDN2
Protein name	Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2)
Synonyms
Description	FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
Accessions	P20800 ENST00000372587.5

EDN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review