I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 21% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of DYRK1B at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 1224.09 | 180 / 180 | 100% | 92.66 | 430 / 430 |
| thymus | 100% | 1947.83 | 653 / 653 | 100% | 40.65 | 604 / 605 |
| adrenal gland | 100% | 2046.28 | 257 / 258 | 100% | 48.18 | 229 / 230 |
| brain | 99% | 1678.45 | 2628 / 2642 | 100% | 26.19 | 702 / 705 |
| prostate | 100% | 1521.54 | 244 / 245 | 99% | 38.00 | 499 / 502 |
| kidney | 100% | 1616.01 | 89 / 89 | 99% | 30.54 | 891 / 901 |
| uterus | 100% | 1447.68 | 170 / 170 | 97% | 32.87 | 447 / 459 |
| breast | 99% | 1256.97 | 456 / 459 | 98% | 35.64 | 1092 / 1118 |
| skin | 100% | 1296.88 | 1804 / 1809 | 95% | 28.85 | 448 / 472 |
| bladder | 100% | 1197.62 | 21 / 21 | 94% | 29.98 | 474 / 504 |
| esophagus | 100% | 1126.67 | 1440 / 1445 | 94% | 27.30 | 172 / 183 |
| lung | 97% | 1025.13 | 560 / 578 | 96% | 27.01 | 1112 / 1155 |
| stomach | 99% | 1013.60 | 356 / 359 | 94% | 24.35 | 268 / 286 |
| pancreas | 93% | 605.94 | 305 / 328 | 97% | 30.29 | 173 / 178 |
| intestine | 99% | 1202.73 | 960 / 966 | 91% | 20.71 | 478 / 527 |
| liver | 77% | 381.12 | 175 / 226 | 75% | 14.32 | 305 / 406 |
| eye | 0% | 0 | 0 / 0 | 100% | 48.91 | 80 / 80 |
| muscle | 100% | 7626.56 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1524.75 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 40.40 | 1 / 1 |
| adipose | 99% | 1006.78 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 858.20 | 1310 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 25.25 | 44 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 20.26 | 28 / 29 |
| heart | 96% | 1032.10 | 829 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 828.65 | 886 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0006281 | Biological process | DNA repair |
| GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0060612 | Biological process | adipose tissue development |
| GO_0007520 | Biological process | myoblast fusion |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005694 | Cellular component | chromosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0004712 | Molecular function | protein serine/threonine/tyrosine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DYRK1B |
| Protein name | dual-specificity kinase (EC 2.7.12.1) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
| Synonyms | MIRK |
| Description | FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance . During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 . Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). . |
| Accessions | ENST00000627034.2 [Q9Y463-2] ENST00000593685.5 ENST00000626964 A0A9H4CVU7 M0R2X3 ENST00000631090.2 [Q9Y463-1] ENST00000625438.2 [Q9Y463-3] ENST00000348817.7 [Q9Y463-3] ENST00000630714 ENST00000600611.5 M0R131 ENST00000625757.3 [Q9Y463-1] ENST00000323039.10 [Q9Y463-1] ENST00000430012.6 [Q9Y463-2] Q9Y463 ENST00000597639.5 [Q9Y463-3] ENST00000625388.2 [Q9Y463-3] ENST00000601972.1 |
