I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 3 studies | 18% ± 0% | |
| GABAergic neuron | 3 studies | 22% ± 5% | |
| glutamatergic neuron | 3 studies | 26% ± 6% | |
| astrocyte | 3 studies | 20% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 3 studies | 18% ± 0% | |
| GABAergic neuron | 3 studies | 22% ± 5% | |
| glutamatergic neuron | 3 studies | 26% ± 6% | |
| astrocyte | 3 studies | 20% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 597.14 | 21 / 21 | 100% | 13.87 | 504 / 504 |
| esophagus | 100% | 658.90 | 1445 / 1445 | 100% | 8.90 | 183 / 183 |
| intestine | 100% | 632.78 | 966 / 966 | 100% | 10.40 | 526 / 527 |
| prostate | 100% | 549.64 | 245 / 245 | 100% | 7.35 | 501 / 502 |
| skin | 100% | 963.10 | 1809 / 1809 | 100% | 9.36 | 471 / 472 |
| uterus | 100% | 514.05 | 170 / 170 | 100% | 12.06 | 458 / 459 |
| lung | 100% | 635.09 | 577 / 578 | 100% | 9.46 | 1154 / 1155 |
| kidney | 100% | 485.42 | 89 / 89 | 99% | 7.77 | 896 / 901 |
| breast | 100% | 557.95 | 459 / 459 | 99% | 8.69 | 1111 / 1118 |
| thymus | 100% | 535.83 | 653 / 653 | 99% | 6.85 | 601 / 605 |
| stomach | 100% | 439.74 | 359 / 359 | 99% | 9.35 | 284 / 286 |
| brain | 99% | 429.47 | 2612 / 2642 | 100% | 10.88 | 705 / 705 |
| ovary | 100% | 449.19 | 180 / 180 | 99% | 5.30 | 424 / 430 |
| liver | 100% | 438.98 | 226 / 226 | 98% | 5.98 | 397 / 406 |
| adrenal gland | 100% | 582.24 | 258 / 258 | 97% | 6.32 | 224 / 230 |
| pancreas | 92% | 212.96 | 303 / 328 | 99% | 8.77 | 177 / 178 |
| adipose | 100% | 529.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 28.17 | 29 / 29 |
| spleen | 100% | 1333.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 11.58 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.20 | 1 / 1 |
| blood vessel | 100% | 397.87 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 386.04 | 798 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 1199.09 | 919 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 7.85 | 79 / 80 |
| heart | 95% | 325.39 | 820 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002943 | Biological process | tRNA dihydrouridine synthesis |
| GO_0140374 | Biological process | antiviral innate immune response |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004860 | Molecular function | protein kinase inhibitor activity |
| GO_0102264 | Molecular function | tRNA-dihydrouridine20 synthase activity |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0070402 | Molecular function | NADPH binding |
| GO_0010181 | Molecular function | FMN binding |
| GO_0017150 | Molecular function | tRNA dihydrouridine synthase activity |
| GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003725 | Molecular function | double-stranded RNA binding |
| Gene name | DUS2 |
| Protein name | Dihydrouridine synthase 2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) |
| Synonyms | DUS2L |
| Description | FUNCTION: Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs . Negatively regulates the activation of EIF2AK2/PKR . . |
| Accessions | I3L1K5 H3BM64 ENST00000570709.6 ENST00000562246.2 ENST00000576994.5 ENST00000568099.6 I3L4H0 H3BQX4 ENST00000567100.5 ENST00000575677.5 E7EUN9 Q9NX74 ENST00000566306.5 H3BMK6 ENST00000432752.5 ENST00000358896.10 ENST00000564781.1 I3L4Y9 H3BRI6 ENST00000565263.6 ENST00000569289.5 H3BSF3 J3QLD5 ENST00000571081.6 I3L0K0 H3BTR3 ENST00000561965.1 |
