DTL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DTL at tissue level.

III. Associated gene sets

GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0000209Biological processprotein polyubiquitination
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0009411Biological processresponse to UV
GO_0006260Biological processDNA replication
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0019985Biological processtranslesion synthesis
GO_0006513Biological processprotein monoubiquitination
GO_0048511Biological processrhythmic process
GO_0051726Biological processregulation of cell cycle
GO_0005730Cellular componentnucleolus
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0031465Cellular componentCul4B-RING E3 ubiquitin ligase complex
GO_0005694Cellular componentchromosome
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDTL
Protein nameDenticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
Denticleless E3 ubiquitin protein ligase homolog
SynonymsL2DTL
RAMP
DCAF2
CDW1
CDT2
DescriptionFUNCTION: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 . CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication . CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing . KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration . Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis . The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 . .

AccessionsENST00000542077.5
ENST00000366991.5 [Q9NZJ0-1]
F5GZ90
Q9NZJ0