DTD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0106074Biological processaminoacyl-tRNA metabolism involved in translational fidelity
GO_0006399Biological processtRNA metabolic process
GO_0006260Biological processDNA replication
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000049Molecular functiontRNA binding
GO_0051500Molecular functionD-tyrosyl-tRNA(Tyr) deacylase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDTD1
Protein nameD-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related)
D-aminoacyl-tRNA deacylase (EC 3.1.1.96)
SynonymsDUEB
HARS2
C20orf88
DescriptionFUNCTION: Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes . .; FUNCTION: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. .

AccessionsQ8TEA8
ENST00000377452.4
A0A2R8Y6X2
A0A2R8YCT7
Q496C9
ENST00000494921.2
ENST00000647441.1