DPF3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	13 studies	43% ± 19%	Explore
oligodendrocyte	10 studies	36% ± 12%	Explore
oligodendrocyte precursor cell	9 studies	40% ± 16%	Explore
retinal cone cell	8 studies	52% ± 20%	Explore
retinal rod cell	7 studies	38% ± 20%	Explore
glutamatergic neuron	5 studies	34% ± 5%	Explore
amacrine cell	5 studies	34% ± 19%	Explore
cardiac muscle cell	5 studies	60% ± 16%	Explore
granule cell	4 studies	51% ± 9%	Explore
interneuron	4 studies	51% ± 12%	Explore
neuron	4 studies	36% ± 14%	Explore
GABAergic neuron	4 studies	27% ± 6%	Explore
GABAergic amacrine cell	3 studies	40% ± 5%	Explore
glycinergic amacrine cell	3 studies	46% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	30% ± 10%	Explore
eye	5 studies	31% ± 16%	Explore
heart	3 studies	29% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	950.32	2631 / 2642	99%	9.55	697 / 705
adrenal gland	87%	245.66	224 / 258	76%	2.35	174 / 230
ovary	99%	1977.94	178 / 180	53%	1.49	226 / 430
kidney	84%	391.85	75 / 89	58%	2.52	527 / 901
liver	91%	382.28	206 / 226	20%	0.44	83 / 406
muscle	100%	2169.92	803 / 803	0%	0	0 / 0
heart	97%	1259.85	833 / 861	0%	0	0 / 0
spleen	94%	253.57	226 / 241	0%	0	0 / 0
intestine	70%	285.03	674 / 966	21%	0.42	109 / 527
skin	51%	176.55	921 / 1809	35%	0.88	167 / 472
blood vessel	52%	141.83	698 / 1335	0%	0	0 / 0
breast	34%	69.78	155 / 459	15%	0.33	165 / 1118
lymph node	0%	0	0 / 0	48%	1.21	14 / 29
thymus	24%	49.66	158 / 653	14%	0.19	85 / 605
esophagus	24%	67.56	349 / 1445	5%	0.09	9 / 183
uterus	8%	18.75	13 / 170	14%	0.29	63 / 459
stomach	9%	16.16	33 / 359	12%	0.22	34 / 286
bladder	14%	28.05	3 / 21	7%	0.18	33 / 504
lung	10%	19.01	55 / 578	5%	0.09	52 / 1155
pancreas	2%	3.45	7 / 328	11%	0.17	20 / 178
adipose	13%	24.06	159 / 1204	0%	0	0 / 0
peripheral blood	10%	30.07	95 / 929	0%	0	0 / 0
prostate	7%	15.11	18 / 245	1%	0.02	5 / 502
eye	0%	0	0 / 0	6%	0.20	5 / 80
tonsil	0%	0	0 / 0	2%	0.04	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0070316	Biological process	regulation of G0 to G1 transition
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0030071	Biological process	regulation of mitotic metaphase/anaphase transition
GO_0007399	Biological process	nervous system development
GO_2000781	Biological process	positive regulation of double-strand break repair
GO_0008150	Biological process	biological_process
GO_0006338	Biological process	chromatin remodeling
GO_0007517	Biological process	muscle organ development
GO_2000819	Biological process	regulation of nucleotide-excision repair
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0035060	Cellular component	brahma complex
GO_0071565	Cellular component	nBAF complex
GO_0016514	Cellular component	SWI/SNF complex
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	DPF3
Protein name	Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4) Double PHD fingers 3
Synonyms	CERD4 BAF45C
Description	FUNCTION: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. .; FUNCTION: [Isoform 2]: Acts as a regulator of myogenesis in cooperation with HDGFL2 . Mediates the interaction of HDGFL2 with the BAF complex . HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters . .
Accessions	ENST00000366353.8 F8W7T1 ENST00000614862.5 [Q92784-5] ENST00000381216.8 [Q92784-2] ENST00000556509.6 [Q92784-1] Q92784

DPF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review