DNTT report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DNTT at tissue level.

III. Associated gene sets

GO_0071897Biological processDNA biosynthetic process
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0006259Biological processDNA metabolic process
GO_0006304Biological processDNA modification
GO_0033198Biological processresponse to ATP
GO_0016363Cellular componentnuclear matrix
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003912Molecular functionDNA nucleotidylexotransferase activity
GO_0003887Molecular functionDNA-directed DNA polymerase activity
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDNTT
Protein nameDNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase)
Deoxynucleotidyltransferase
SynonymsTDT
DescriptionFUNCTION: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. .

AccessionsQ14182
P04053
ENST00000630152.1 [P04053-2]
ENST00000371174.5 [P04053-1]