DNASE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043353Biological processenucleate erythrocyte differentiation
GO_0006309Biological processapoptotic DNA fragmentation
GO_0006259Biological processDNA metabolic process
GO_0050776Biological processregulation of immune response
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0003677Molecular functionDNA binding
GO_0004531Molecular functiondeoxyribonuclease II activity

IV. Literature review

[source]
Gene nameDNASE2
Protein nameDeoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (Lysosomal DNase II)
Deoxyribonuclease II
Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)
SynonymsDNL2
DNASE2A
DescriptionFUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation . Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells . .

FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. .

FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. .

AccessionsK7ENE5
Q9H3R9
Q96TC5
O00115
ENST00000698693.1
ENST00000592506.2 [O00115-2]
ENST00000222219.8 [O00115-1]
ENST00000592506.1
A0A8V8TNK3