DNAJC9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0006334Biological processnucleosome assembly
GO_0005615Cellular componentextracellular space
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0031072Molecular functionheat shock protein binding
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameDNAJC9
Protein nameDnaJ homolog subfamily C member 9 (HDJC9) (DnaJ protein SB73)
Synonyms
DescriptionFUNCTION: Acts as a dual histone chaperone and heat shock co-chaperone . As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes . May also act as a histone co-chaperone together with TONSL . May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers . Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 . As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity . Exhibits activity to assemble histones onto DNA in vitro . .

AccessionsQ8WXX5
ENST00000372950.6