Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 17 studies | 69% ± 21% | |
glutamatergic neuron | 13 studies | 55% ± 26% | |
GABAergic neuron | 11 studies | 50% ± 27% | |
oligodendrocyte precursor cell | 11 studies | 39% ± 15% | |
astrocyte | 8 studies | 32% ± 18% | |
neuron | 7 studies | 41% ± 14% | |
interneuron | 6 studies | 54% ± 27% | |
retinal ganglion cell | 6 studies | 44% ± 18% | |
endothelial cell | 5 studies | 48% ± 15% | |
granule cell | 4 studies | 51% ± 13% | |
amacrine cell | 4 studies | 32% ± 18% | |
retinal cone cell | 4 studies | 27% ± 14% | |
retina horizontal cell | 4 studies | 40% ± 18% | |
retinal rod cell | 4 studies | 26% ± 9% | |
GABAergic interneuron | 3 studies | 51% ± 4% | |
glial cell | 3 studies | 27% ± 12% | |
microglial cell | 3 studies | 29% ± 5% | |
OFF-bipolar cell | 3 studies | 29% ± 12% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 10113.69 | 2631 / 2642 | 100% | 46.20 | 702 / 705 |
adrenal gland | 78% | 1181.66 | 202 / 258 | 94% | 24.49 | 217 / 230 |
kidney | 36% | 331.28 | 32 / 89 | 72% | 4.45 | 646 / 901 |
skin | 8% | 92.63 | 137 / 1809 | 60% | 5.14 | 282 / 472 |
intestine | 20% | 202.56 | 195 / 966 | 46% | 2.11 | 241 / 527 |
lung | 10% | 86.46 | 58 / 578 | 44% | 2.36 | 510 / 1155 |
breast | 4% | 31.76 | 18 / 459 | 47% | 2.95 | 527 / 1118 |
stomach | 5% | 45.85 | 19 / 359 | 44% | 2.08 | 125 / 286 |
esophagus | 3% | 28.63 | 47 / 1445 | 40% | 1.80 | 74 / 183 |
ovary | 0% | 0 | 0 / 180 | 42% | 1.57 | 181 / 430 |
thymus | 1% | 4.87 | 4 / 653 | 39% | 1.35 | 238 / 605 |
heart | 38% | 488.87 | 329 / 861 | 0% | 0 | 0 / 0 |
liver | 0% | 3.93 | 1 / 226 | 37% | 2.09 | 149 / 406 |
prostate | 1% | 6.96 | 2 / 245 | 34% | 1.23 | 171 / 502 |
lymph node | 0% | 0 | 0 / 0 | 31% | 1.96 | 9 / 29 |
bladder | 5% | 31.90 | 1 / 21 | 26% | 1.31 | 130 / 504 |
pancreas | 0% | 2.16 | 1 / 328 | 27% | 2.08 | 48 / 178 |
uterus | 0% | 0 | 0 / 170 | 21% | 0.94 | 98 / 459 |
eye | 0% | 0 | 0 / 0 | 21% | 1.22 | 17 / 80 |
adipose | 8% | 72.92 | 102 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 8% | 65.27 | 103 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 7% | 0.22 | 3 / 45 |
spleen | 5% | 39.88 | 11 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 1% | 6.70 | 7 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0036465 | Biological process | synaptic vesicle recycling |
GO_0046907 | Biological process | intracellular transport |
GO_0016191 | Biological process | synaptic vesicle uncoating |
GO_1905443 | Biological process | regulation of clathrin coat assembly |
GO_0072318 | Biological process | clathrin coat disassembly |
GO_2000369 | Biological process | regulation of clathrin-dependent endocytosis |
GO_0072583 | Biological process | clathrin-dependent endocytosis |
GO_0030136 | Cellular component | clathrin-coated vesicle |
GO_0098894 | Cellular component | extrinsic component of presynaptic endocytic zone membrane |
GO_0005829 | Cellular component | cytosol |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0031982 | Cellular component | vesicle |
GO_0032050 | Molecular function | clathrin heavy chain binding |
GO_0031072 | Molecular function | heat shock protein binding |
GO_0030276 | Molecular function | clathrin binding |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
Gene name | DNAJC6 |
Protein name | DnaJ heat shock protein family (Hsp40) member C6 DnaJ (Hsp40) homolog, subfamily C, member 6 Auxilin (EC 3.1.3.-) (DnaJ homolog subfamily C member 6) |
Synonyms | KIAA0473 |
Description | FUNCTION: May act as a protein phosphatase and/or a lipid phosphatase. Co-chaperone that recruits HSPA8/HSC70 to clathrin-coated vesicles (CCVs) and promotes the ATP-dependent dissociation of clathrin from CCVs and participates in clathrin-mediated endocytosis of synaptic vesicles and their recycling and also in intracellular trafficking . Firstly, binds tightly to the clathrin cages, at a ratio of one DNAJC6 per clathrin triskelion. The HSPA8:ATP complex then binds to the clathrin-auxilin cage, initially at a ratio of one HSPA8 per triskelion leading to ATP hydrolysis stimulation and causing a conformational change in the HSPA8. This cycle is repeated three times to drive to a complex containing the clathrin-auxilin cage associated to three HSPA8:ADP complex. The ATP hydrolysis of the third HSPA8:ATP complex leads to a concerted dismantling of the cage into component triskelia. Then, dissociates from the released triskelia and be recycled to initiate another cycle of HSPA8's recruitment. Also acts during the early steps of clathrin-coated vesicle (CCV) formation through its interaction with the GTP bound form of DNM1 (By similarity). . |
Accessions | ENST00000395325.7 [O75061-1] O75061 ENST00000494710.6 S4R305 ENST00000263441.11 [O75061-4] ENST00000371069.5 [O75061-2] L0N9S0 |