Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 15 studies | 36% ± 13% | |
| astrocyte | 8 studies | 25% ± 8% | |
| GABAergic neuron | 6 studies | 31% ± 13% | |
| glutamatergic neuron | 6 studies | 34% ± 16% | |
| endothelial cell | 5 studies | 25% ± 7% | |
| ciliated cell | 5 studies | 32% ± 9% | |
| neuron | 4 studies | 35% ± 11% | |
| fibroblast | 4 studies | 22% ± 4% | |
| epithelial cell | 4 studies | 30% ± 5% | |
| amacrine cell | 4 studies | 31% ± 10% | |
| retinal bipolar neuron | 3 studies | 32% ± 8% | |
| squamous epithelial cell | 3 studies | 31% ± 14% | |
| retina horizontal cell | 3 studies | 28% ± 7% | |
| retinal cone cell | 3 studies | 42% ± 11% | |
| retinal rod cell | 3 studies | 24% ± 3% | |
| interneuron | 3 studies | 33% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 10422.21 | 258 / 258 | 100% | 84.42 | 230 / 230 |
| pancreas | 100% | 5076.69 | 328 / 328 | 100% | 69.92 | 178 / 178 |
| thymus | 100% | 8662.71 | 653 / 653 | 100% | 100.84 | 605 / 605 |
| uterus | 100% | 6896.52 | 170 / 170 | 100% | 67.21 | 459 / 459 |
| brain | 100% | 17157.73 | 2641 / 2642 | 100% | 119.40 | 705 / 705 |
| prostate | 100% | 8844.02 | 245 / 245 | 100% | 98.31 | 501 / 502 |
| kidney | 100% | 7463.21 | 89 / 89 | 99% | 52.88 | 896 / 901 |
| skin | 100% | 8459.15 | 1800 / 1809 | 100% | 58.21 | 471 / 472 |
| breast | 100% | 5537.73 | 459 / 459 | 99% | 65.62 | 1108 / 1118 |
| liver | 99% | 4160.35 | 224 / 226 | 99% | 45.50 | 403 / 406 |
| bladder | 100% | 6171.38 | 21 / 21 | 98% | 50.14 | 494 / 504 |
| intestine | 100% | 5287.12 | 965 / 966 | 98% | 35.58 | 516 / 527 |
| lung | 99% | 5567.97 | 574 / 578 | 97% | 50.53 | 1126 / 1155 |
| esophagus | 100% | 5423.84 | 1443 / 1445 | 96% | 24.46 | 176 / 183 |
| stomach | 100% | 4813.55 | 358 / 359 | 92% | 28.24 | 263 / 286 |
| ovary | 100% | 7028.76 | 180 / 180 | 91% | 25.80 | 390 / 430 |
| eye | 0% | 0 | 0 / 0 | 100% | 76.32 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 62.64 | 29 / 29 |
| muscle | 100% | 8128.58 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5591.08 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 62.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 42.30 | 1 / 1 |
| adipose | 100% | 4880.36 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5172.97 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 5330.35 | 843 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 96% | 4064.93 | 895 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0090084 | Biological process | negative regulation of inclusion body assembly |
| GO_0006986 | Biological process | response to unfolded protein |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0032781 | Biological process | positive regulation of ATP-dependent activity |
| GO_0061077 | Biological process | chaperone-mediated protein folding |
| GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO_0031396 | Biological process | regulation of protein ubiquitination |
| GO_0070050 | Biological process | neuron cellular homeostasis |
| GO_1903644 | Biological process | regulation of chaperone-mediated protein folding |
| GO_0042026 | Biological process | protein refolding |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0001671 | Molecular function | ATPase activator activity |
| GO_0051082 | Molecular function | unfolded protein binding |
| GO_0120283 | Molecular function | protein serine/threonine kinase binding |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0030544 | Molecular function | Hsp70 protein binding |
| GO_0140318 | Molecular function | protein transporter activity |
| GO_0140036 | Molecular function | ubiquitin-modified protein reader activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0043130 | Molecular function | ubiquitin binding |
| Gene name | DNAJB2 |
| Protein name | DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1) DnaJ heat shock protein family (Hsp40) member B2 |
| Synonyms | HSPF3 HSJ1 |
| Description | FUNCTION: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family . In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins . Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes . Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins . . |
| Accessions | E7ETU0 ENST00000336576.10 [P25686-3] ENST00000442681.5 C9JXB9 P25686 ENST00000425450.5 C9J1G2 ENST00000392086.8 [P25686-2] C9JX00 ENST00000421532.5 ENST00000392087.6 C9JRD2 ENST00000439026.1 |