DNAJB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090084Biological processnegative regulation of inclusion body assembly
GO_0006986Biological processresponse to unfolded protein
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0061077Biological processchaperone-mediated protein folding
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0031396Biological processregulation of protein ubiquitination
GO_0070050Biological processneuron cellular homeostasis
GO_1903644Biological processregulation of chaperone-mediated protein folding
GO_0042026Biological processprotein refolding
GO_0032091Biological processnegative regulation of protein binding
GO_0036503Biological processERAD pathway
GO_0030308Biological processnegative regulation of cell growth
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0001671Molecular functionATPase activator activity
GO_0051082Molecular functionunfolded protein binding
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0030544Molecular functionHsp70 protein binding
GO_0140318Molecular functionprotein transporter activity
GO_0140036Molecular functionubiquitin-modified protein reader activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameDNAJB2
Protein nameDnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)
DnaJ heat shock protein family (Hsp40) member B2
SynonymsHSPF3
HSJ1
DescriptionFUNCTION: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family . In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins . Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes . Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins . .

AccessionsE7ETU0
ENST00000336576.10 [P25686-3]
ENST00000442681.5
C9JXB9
P25686
ENST00000425450.5
C9J1G2
ENST00000392086.8 [P25686-2]
C9JX00
ENST00000421532.5
ENST00000392087.6
C9JRD2
ENST00000439026.1