DIS3L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016075Biological processrRNA catabolic process
GO_0006401Biological processRNA catabolic process
GO_0006402Biological processmRNA catabolic process
GO_0006396Biological processRNA processing
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding
GO_0008859Molecular functionexoribonuclease II activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDIS3L
Protein nameAlternative protein DIS3L
DIS3-like exonuclease 1 (EC 3.1.13.1)
DIS3 like exosome 3'-5' exoribonuclease
SynonymsKIAA1955
DIS3L1
DescriptionFUNCTION: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events . In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA . .

AccessionsENST00000319194.9 [Q8TF46-4]
ENST00000530615.1
E9PKI7
E9PI27
ENST00000525134.6
E9PS35
ENST00000319212.9 [Q8TF46-1]
ENST00000525109.1
ENST00000530537.1
E9PIL0
ENST00000524795.5
E9PI20
L8E9K1
ENST00000532580.5
Q8TF46