DHX37 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DHX37 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHX37 at tissue level.

III. Associated gene sets

GO_0042254Biological processribosome biogenesis
GO_0042274Biological processribosomal small subunit biogenesis
GO_2000020Biological processpositive regulation of male gonad development
GO_0007420Biological processbrain development
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0042255Biological processribosome assembly
GO_0005730Cellular componentnucleolus
GO_0005622Cellular componentintracellular anatomical structure
GO_0032040Cellular componentsmall-subunit processome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0034511Molecular functionU3 snoRNA binding
GO_0004386Molecular functionhelicase activity
GO_0003724Molecular functionRNA helicase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDHX37
Protein nameDHX37 protein
RNA helicase (EC 3.6.4.13)
Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37)
SynonymsDDX37
KIAA1517
DescriptionFUNCTION: ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis . Required for the release of the U3 snoRNP from pre-ribosomal particles . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . Plays a role in early testis development . Probably also plays a role in brain development . .

AccessionsENST00000308736.7
F5H3Y4
Q8IY37
Q6IPP7
ENST00000544745.2