DHODH | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell of lymphatic vessel	4 studies	25% ± 7%	Explore
hepatocyte	3 studies	39% ± 32%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHODH at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	8881.19	226 / 226	100%	18.19	405 / 406
prostate	100%	654.87	245 / 245	100%	7.74	500 / 502
brain	99%	408.90	2626 / 2642	100%	8.41	705 / 705
uterus	100%	729.11	170 / 170	99%	7.05	456 / 459
kidney	100%	608.38	89 / 89	99%	7.27	892 / 901
lung	100%	612.33	576 / 578	99%	6.52	1147 / 1155
breast	100%	731.94	459 / 459	99%	5.75	1106 / 1118
esophagus	100%	541.64	1445 / 1445	99%	4.98	181 / 183
skin	100%	615.46	1808 / 1809	99%	7.98	467 / 472
bladder	100%	623.05	21 / 21	99%	6.74	498 / 504
intestine	100%	584.97	965 / 966	98%	7.45	518 / 527
ovary	100%	776.99	180 / 180	98%	5.10	422 / 430
thymus	100%	762.67	653 / 653	98%	5.13	591 / 605
pancreas	99%	399.84	325 / 328	98%	5.12	174 / 178
stomach	100%	482.58	358 / 359	97%	6.37	277 / 286
adrenal gland	100%	613.54	258 / 258	95%	4.56	218 / 230
adipose	100%	827.21	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	7.78	29 / 29
muscle	100%	608.87	803 / 803	0%	0	0 / 0
spleen	100%	733.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	5.41	45 / 45
ureter	0%	0	0 / 0	100%	4.12	1 / 1
blood vessel	100%	484.35	1332 / 1335	0%	0	0 / 0
heart	98%	1037.21	844 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	6.24	76 / 80
peripheral blood	74%	398.33	684 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006207	Biological process	'de novo' pyrimidine nucleobase biosynthetic process
GO_0009220	Biological process	pyrimidine ribonucleotide biosynthetic process
GO_0006225	Biological process	UDP biosynthetic process
GO_0044205	Biological process	'de novo' UMP biosynthetic process
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0106430	Molecular function	dihydroorotate dehydrogenase (quinone) activity
GO_0004152	Molecular function	dihydroorotate dehydrogenase activity
GO_0004151	Molecular function	dihydroorotase activity
GO_0005515	Molecular function	protein binding

Gene name	DHODH
Protein name	Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) Dihydroorotate dehydrogenase (quinone)
Synonyms
Description	FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. . FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. .
Accessions	I3NI32 I3L449 ENST00000576145.1 J3QRJ4 ENST00000572887.5 J3QRQ3 ENST00000219240.9 ENST00000571288.6 ENST00000574309.5 Q02127

DHODH report