DHH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DHH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DHH at tissue level.

III. Associated gene sets

GO_0032355Biological processresponse to estradiol
GO_0010468Biological processregulation of gene expression
GO_0007224Biological processsmoothened signaling pathway
GO_0030238Biological processmale sex determination
GO_0001708Biological processcell fate specification
GO_0043627Biological processresponse to estrogen
GO_0042552Biological processmyelination
GO_0001649Biological processosteoblast differentiation
GO_0016540Biological processprotein autoprocessing
GO_0050810Biological processregulation of steroid biosynthetic process
GO_0007267Biological processcell-cell signaling
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0097264Biological processself proteolysis
GO_0033327Biological processLeydig cell differentiation
GO_0007286Biological processspermatid development
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000139Cellular componentGolgi membrane
GO_0008233Molecular functionpeptidase activity
GO_0008270Molecular functionzinc ion binding
GO_0005113Molecular functionpatched binding
GO_0140853Molecular functioncholesterol-protein transferase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDHH
Protein nameMutant desert hedgehog
Hedgehog protein
Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into: Desert hedgehog protein N-product (DHH-N)]
Synonyms
DescriptionFUNCTION: [Desert hedgehog protein]: The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Functions in cell-cell mediated juxtacrine signaling . Promotes endothelium integrity . Binds to PTCH1 receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes in endothelial cells . In Schwann cells, controls the development of the peripheral nerve sheath and the transition of mesenchymal cells to form the epithelium-like structure of the perineurial tube (By similarity). .; FUNCTION: [Desert hedgehog protein N-product]: The dually lipidated desert hedgehog protein N-product is essential for a variety of patterning events during development (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes . Required for normal testis development and spermatogenesis, namely for the formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules (By similarity). Activates primary cilia signaling on neighboring valve interstitial cells through a paracrine mechanism (By similarity). May induce motor neurons in lateral neural tube and may have a polarizing activity . Prevents the desert hedgehog protein precursor binding to PTCH1 . .

FUNCTION: [Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. .; FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. .

AccessionsENST00000649637.2
F6KSZ4
O43323
F6KSZ5