I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| basal cell | 3 studies | 21% ± 5% | |
| hepatocyte | 3 studies | 39% ± 32% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 3 studies | 21% ± 5% | |
| hepatocyte | 3 studies | 39% ± 32% |
Insufficient scRNA-seq data for expression of DHCR7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 5824.35 | 180 / 180 | 99% | 66.62 | 427 / 430 |
| liver | 100% | 9773.54 | 226 / 226 | 99% | 138.47 | 403 / 406 |
| brain | 100% | 2654.66 | 2630 / 2642 | 99% | 63.00 | 700 / 705 |
| adrenal gland | 100% | 10248.07 | 258 / 258 | 96% | 142.14 | 221 / 230 |
| prostate | 96% | 1777.53 | 235 / 245 | 99% | 71.26 | 498 / 502 |
| breast | 97% | 1808.09 | 443 / 459 | 98% | 86.10 | 1100 / 1118 |
| lung | 94% | 2701.42 | 545 / 578 | 97% | 91.38 | 1119 / 1155 |
| thymus | 96% | 1444.05 | 630 / 653 | 92% | 36.79 | 556 / 605 |
| stomach | 90% | 1554.06 | 323 / 359 | 98% | 74.16 | 279 / 286 |
| esophagus | 78% | 1981.62 | 1130 / 1445 | 98% | 131.56 | 179 / 183 |
| bladder | 76% | 836.05 | 16 / 21 | 97% | 77.52 | 490 / 504 |
| skin | 99% | 6162.96 | 1794 / 1809 | 74% | 48.35 | 349 / 472 |
| kidney | 96% | 1662.09 | 85 / 89 | 78% | 24.55 | 699 / 901 |
| pancreas | 76% | 821.71 | 248 / 328 | 97% | 43.81 | 173 / 178 |
| intestine | 75% | 1409.90 | 722 / 966 | 98% | 86.52 | 516 / 527 |
| uterus | 76% | 1273.36 | 130 / 170 | 95% | 52.47 | 434 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 82.26 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 59.54 | 1 / 1 |
| adipose | 94% | 2059.18 | 1136 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 94% | 1080.33 | 226 / 241 | 0% | 0 | 0 / 0 |
| heart | 90% | 1897.93 | 778 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 73% | 827.45 | 975 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 72% | 2273.99 | 665 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 64% | 17.41 | 51 / 80 |
| muscle | 44% | 386.74 | 353 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 11.75 | 12 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0033490 | Biological process | cholesterol biosynthetic process via lathosterol |
| GO_0016132 | Biological process | brassinosteroid biosynthetic process |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0033489 | Biological process | cholesterol biosynthetic process via desmosterol |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005640 | Cellular component | nuclear outer membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0050661 | Molecular function | NADP binding |
| GO_0047598 | Molecular function | 7-dehydrocholesterol reductase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DHCR7 |
| Protein name | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2) 7-dehydrocholesterol reductase isoform 4 7-dehydrocholesterol reductase (EC 1.3.1.21) (Sterol Delta(7)-reductase) 7-dehydrocholesterol reductase 7-dehydrocholesterol reductase isoform 3 7-dehydrocholesterol reductase isoform 2 7-dehydrocholesterol reductase isoform C |
| Synonyms | hCG_2017142 D7SR |
| Description | FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . FUNCTION: 7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. . |
| Accessions | A0A0S2Z3S3 A0A0S2Z3N8 X5DNI9 ENST00000525346 H0YCS7 ENST00000533800.5 E9PM00 ENST00000529990.6 E9PRL8 ENST00000683287.1 H0YEJ5 A0A804HL56 E9PQ71 E9PLZ2 ENST00000525346.6 E9PJ54 H0YE57 ENST00000527452.1 ENST00000407721.6 A0A1Y1BG54 A0A804HJI8 A0A0S2Z3U5 ENST00000526780.6 ENST00000525137.1 X5DRD7 A0A1Y1BBN3 ENST00000531364.5 ENST00000534795.5 ENST00000526780 ENST00000685320.1 Q9UBM7 A0A8I5KRR9 ENST00000527316.6 A0A024R5F7 X5D9E1 ENST00000690257.1 E9PIP9 A0A1Y1B909 ENST00000355527.8 B4E1K5 ENST00000682708.1 ENST00000682880.1 A0A804HJQ7 A0A804HI25 ENST00000683714.1 |
