DGKH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0046339Biological processdiacylglycerol metabolic process
GO_0046473Biological processphosphatidic acid metabolic process
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0030168Biological processplatelet activation
GO_0046834Biological processlipid phosphorylation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0015629Cellular componentactin cytoskeleton
GO_0005768Cellular componentendosome
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameDGKH
Protein nameDiacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta)
Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
Diacylglycerol kinase eta
Synonyms
DescriptionFUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) . Plays a key role in promoting cell growth . Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF . Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization . .

AccessionsENST00000261491.9 [Q86XP1-2]
A0A0D9SF65
ENST00000626247.2
ENST00000536612.3 [Q86XP1-3]
ENST00000379274.6 [Q86XP1-2]
ENST00000628433.2 [Q86XP1-5]
A0A0D9SFR6
ENST00000337343.9 [Q86XP1-1]
ENST00000627777.2
A0A087WZ02
Q86XP1
ENST00000611224.1