Insufficient scRNA-seq data for expression of DGAT2 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 97% | 9283.08 | 220 / 226 | 95% | 40.73 | 386 / 406 |
| breast | 66% | 11065.12 | 305 / 459 | 87% | 12.23 | 972 / 1118 |
| bladder | 38% | 754.52 | 8 / 21 | 91% | 16.34 | 461 / 504 |
| skin | 73% | 8818.76 | 1316 / 1809 | 56% | 3.69 | 266 / 472 |
| esophagus | 21% | 449.30 | 298 / 1445 | 83% | 7.61 | 151 / 183 |
| ureter | 0% | 0 | 0 / 0 | 100% | 18.73 | 1 / 1 |
| intestine | 4% | 376.72 | 43 / 966 | 95% | 10.87 | 501 / 527 |
| stomach | 4% | 175.96 | 13 / 359 | 95% | 11.98 | 271 / 286 |
| thymus | 14% | 362.39 | 91 / 653 | 84% | 11.80 | 506 / 605 |
| adipose | 88% | 16173.44 | 1065 / 1204 | 0% | 0 | 0 / 0 |
| lung | 10% | 155.74 | 56 / 578 | 78% | 5.29 | 899 / 1155 |
| peripheral blood | 83% | 10873.71 | 767 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 3% | 85.79 | 9 / 328 | 79% | 6.12 | 141 / 178 |
| uterus | 0% | 0 | 0 / 170 | 76% | 6.21 | 349 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 6.11 | 33 / 45 |
| ovary | 0% | 0 | 0 / 180 | 72% | 3.81 | 311 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 69% | 3.42 | 20 / 29 |
| prostate | 1% | 12.69 | 2 / 245 | 54% | 2.11 | 272 / 502 |
| brain | 13% | 239.13 | 340 / 2642 | 40% | 1.44 | 283 / 705 |
| adrenal gland | 6% | 126.24 | 16 / 258 | 47% | 3.09 | 107 / 230 |
| spleen | 49% | 960.31 | 118 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 26% | 0.79 | 21 / 80 |
| kidney | 1% | 128.34 | 1 / 89 | 9% | 0.54 | 83 / 901 |
| blood vessel | 10% | 752.01 | 127 / 1335 | 0% | 0 | 0 / 0 |
| heart | 9% | 307.99 | 78 / 861 | 0% | 0 | 0 / 0 |
| muscle | 1% | 22.55 | 9 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097006 | Biological process | regulation of plasma lipoprotein particle levels |
| GO_0006640 | Biological process | monoacylglycerol biosynthetic process |
| GO_0055089 | Biological process | fatty acid homeostasis |
| GO_0035336 | Biological process | long-chain fatty-acyl-CoA metabolic process |
| GO_0046339 | Biological process | diacylglycerol metabolic process |
| GO_0019432 | Biological process | triglyceride biosynthetic process |
| GO_0060613 | Biological process | fat pad development |
| GO_0019915 | Biological process | lipid storage |
| GO_0034383 | Biological process | low-density lipoprotein particle clearance |
| GO_0042572 | Biological process | retinol metabolic process |
| GO_0071400 | Biological process | cellular response to oleic acid |
| GO_0006651 | Biological process | diacylglycerol biosynthetic process |
| GO_0006071 | Biological process | glycerol metabolic process |
| GO_0035356 | Biological process | intracellular triglyceride homeostasis |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_1990578 | Cellular component | perinuclear endoplasmic reticulum membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0003846 | Molecular function | 2-acylglycerol O-acyltransferase activity |
| GO_0004144 | Molecular function | diacylglycerol O-acyltransferase activity |
| GO_0050252 | Molecular function | retinol O-fatty-acyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DGAT2 |
| Protein name | Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2) Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (EC 2.3.1.76) (Acyl-CoA retinol O-fatty-acyltransferase) (Diglyceride acyltransferase 2) |
| Synonyms | UNQ738/PRO1433 HMFN1045 |
| Description | FUNCTION: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides . Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) . . |
| Accessions | ENST00000376262.7 [Q96PD7-2] ENST00000604733.5 ENST00000228027.12 [Q96PD7-1] S4R3S3 Q96PD7 ENST00000603276.5 S4R449 ENST00000604935.5 ENST00000605099.1 S4R383 S4R3Z3 |
