DERL3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DERL3 at tissue level.

III. Associated gene sets

GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_1904153Biological processnegative regulation of retrograde protein transport, ER to cytosol
GO_0018279Biological processprotein N-linked glycosylation via asparagine
GO_0036503Biological processERAD pathway
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0005047Molecular functionsignal recognition particle binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDERL3
Protein nameDerlin-3 (Degradation in endoplasmic reticulum protein 3) (DERtrin-3) (Der1-like protein 3)
Derlin
SynonymsLLN2
DER3
C22orf14
DescriptionFUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins . May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation . .

FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. .

AccessionsE7EVA4
ENST00000318109.12 [Q96Q80-1]
ENST00000620697.3 [Q96Q80-2]
ENST00000628868.1 [Q96Q80-5]
ENST00000404056.1
Q96Q80
ENST00000476077.1 [Q96Q80-5]
ENST00000614504.3
ENST00000631305.2 [Q96Q80-1]
ENST00000406855.7 [Q96Q80-2]