Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 5 studies | 22% ± 7% | |
| astrocyte | 5 studies | 27% ± 8% | |
| glutamatergic neuron | 4 studies | 42% ± 17% | |
| oligodendrocyte | 4 studies | 22% ± 4% | |
| mast cell | 4 studies | 19% ± 4% | |
| microglial cell | 3 studies | 23% ± 2% | |
| GABAergic neuron | 3 studies | 42% ± 11% | |
| oligodendrocyte precursor cell | 3 studies | 25% ± 5% | |
| interneuron | 3 studies | 33% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 32% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1036.10 | 1444 / 1445 | 99% | 2.87 | 181 / 183 |
| bladder | 100% | 1205.76 | 21 / 21 | 99% | 2.82 | 498 / 504 |
| skin | 100% | 1131.48 | 1809 / 1809 | 98% | 3.01 | 464 / 472 |
| uterus | 100% | 1315.86 | 170 / 170 | 98% | 2.91 | 449 / 459 |
| intestine | 100% | 1394.51 | 966 / 966 | 98% | 2.35 | 515 / 527 |
| brain | 99% | 963.13 | 2622 / 2642 | 98% | 3.02 | 693 / 705 |
| thymus | 100% | 1269.76 | 653 / 653 | 98% | 2.48 | 590 / 605 |
| breast | 100% | 1124.37 | 459 / 459 | 97% | 2.55 | 1088 / 1118 |
| stomach | 100% | 927.48 | 359 / 359 | 97% | 2.42 | 278 / 286 |
| pancreas | 98% | 474.75 | 323 / 328 | 97% | 2.29 | 173 / 178 |
| prostate | 100% | 1172.09 | 245 / 245 | 96% | 1.96 | 480 / 502 |
| lung | 100% | 988.69 | 578 / 578 | 95% | 2.42 | 1102 / 1155 |
| kidney | 100% | 1013.10 | 89 / 89 | 94% | 2.11 | 850 / 901 |
| liver | 100% | 1018.60 | 226 / 226 | 91% | 2.29 | 368 / 406 |
| adrenal gland | 100% | 1502.27 | 258 / 258 | 89% | 2.05 | 205 / 230 |
| ovary | 100% | 2209.27 | 180 / 180 | 86% | 1.80 | 371 / 430 |
| adipose | 100% | 1034.20 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 926.28 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 4.73 | 29 / 29 |
| spleen | 100% | 1895.28 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 3.04 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.43 | 1 / 1 |
| muscle | 99% | 587.36 | 796 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 615.56 | 832 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 2.49 | 77 / 80 |
| peripheral blood | 96% | 903.66 | 891 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0010508 | Biological process | positive regulation of autophagy |
| GO_1904262 | Biological process | negative regulation of TORC1 signaling |
| GO_0034198 | Biological process | cellular response to amino acid starvation |
| GO_1990130 | Cellular component | GATOR1 complex |
| GO_0005764 | Cellular component | lysosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0031463 | Cellular component | Cul3-RING ubiquitin ligase complex |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0005096 | Molecular function | GTPase activator activity |
| Gene name | DEPDC5 |
| Protein name | GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5) DEP domain containing 5, GATOR1 subcomplex subunit |
| Synonyms | KIAA0645 |
| Description | FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway . In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling . In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway . Within the GATOR1 complex, DEPDC5 mediates direct interaction with the nucleotide-binding pocket of small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD) and coordinates their nucleotide loading states by promoting RagA/RRAGA or RagB/RRAGB into their GDP-binding state and RagC/RRAGC or RagD/RRAGD into their GTP-binding state . However, it does not execute the GAP activity, which is mediated by NPRL2 . . |
| Accessions | ENST00000469974.6 ENST00000645560.1 A0A2R8Y6Y2 A0A2R8YEI8 ENST00000448753.6 ENST00000651528.2 [O75140-10] ENST00000645755.1 A0A2R8Y6H8 ENST00000400242.8 [O75140-2] A0A2R8Y5P2 A0A2R8Y6V4 ENST00000647343.1 ENST00000473802.1 ENST00000646515.1 ENST00000646969.1 ENST00000643751.2 A0A5F9UWT1 ENST00000646998.1 ENST00000645015.1 H7C1T0 A0A2R8Y7X0 ENST00000642684.1 A0A2R8YEW8 A0A2R8YFS1 ENST00000645711.1 [O75140-9] A0A2R8Y721 C9JGS4 ENST00000433147.2 ENST00000535622.6 [O75140-8] ENST00000645693.1 ENST00000642696.1 [O75140-1] A0A2R8Y5E9 A0A2R8Y7C9 ENST00000644162.1 ENST00000645547.1 H7C3I3 ENST00000382111.6 [O75140-5] A0A2R8YET0 ENST00000645407.1 H0Y770 ENST00000458532.2 A0A2R8Y5K9 A0A2R8Y842 ENST00000382112.8 [O75140-10] ENST00000642974.1 A0A2R8Y5T1 F8WAX3 ENST00000400248.7 [O75140-1] A0A2R8Y6H3 A0A2R8YF97 ENST00000646755.1 [O75140-2] A0A2R8Y5V3 ENST00000645564.1 ENST00000642771.1 A0A2R8Y7U0 ENST00000643395.1 ENST00000456178.6 ENST00000647438.1 ENST00000646465.1 ENST00000644331.1 [O75140-4] ENST00000437411.6 ENST00000645967.1 A0A2R8Y7U6 ENST00000497340.1 ENST00000400246.7 O75140 ENST00000645494.1 ENST00000400249.7 [O75140-4] A0A2R8Y6F4 |
