DEPDC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DEPDC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEPDC1 at tissue level.

III. Associated gene sets

GO_0035556Biological processintracellular signal transduction
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0017053Cellular componenttranscription repressor complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameDEPDC1
Protein nameDEP domain containing 1
DEP domain-containing protein 1A
SynonymsDEPDC1A
DescriptionFUNCTION: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. .

AccessionsENST00000456315.7 [Q5TB30-5]
ENST00000525124.1
ENST00000370966.9 [Q5TB30-2]
E9PL61
ENST00000489862.1
Q5TB30
H0YES2