DEFB118 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFB118 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	19%	0.33	4 / 21	0%	0	0 / 504
esophagus	15%	0.52	222 / 1445	2%	0.06	4 / 183
uterus	9%	0.19	16 / 170	0%	0.10	2 / 459
stomach	6%	0.10	23 / 359	3%	0.05	8 / 286
spleen	7%	0.11	16 / 241	0%	0	0 / 0
lung	6%	0.09	35 / 578	1%	0.01	6 / 1155
intestine	5%	0.11	51 / 966	1%	0.02	6 / 527
kidney	6%	0.09	5 / 89	1%	0.06	6 / 901
breast	6%	0.13	28 / 459	0%	0.00	2 / 1118
heart	6%	0.10	54 / 861	0%	0	0 / 0
ovary	6%	0.08	10 / 180	1%	0.02	3 / 430
peripheral blood	6%	0.09	58 / 929	0%	0	0 / 0
thymus	6%	0.08	38 / 653	0%	0	0 / 605
adipose	5%	0.09	64 / 1204	0%	0	0 / 0
pancreas	5%	0.07	16 / 328	0%	0	0 / 178
liver	5%	0.05	11 / 226	0%	0	0 / 406
skin	5%	0.09	85 / 1809	0%	0	0 / 472
adrenal gland	5%	0.06	12 / 258	0%	0	0 / 230
blood vessel	4%	0.07	54 / 1335	0%	0	0 / 0
brain	3%	0.04	75 / 2642	0%	0	0 / 705
prostate	2%	0.04	6 / 245	0%	0.00	1 / 502
muscle	2%	0.04	19 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0031640	Biological process	killing of cells of another organism
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0007283	Biological process	spermatogenesis
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_0042742	Biological process	defense response to bacterium
GO_0045087	Biological process	innate immune response
GO_0007160	Biological process	cell-matrix adhesion
GO_0031665	Biological process	negative regulation of lipopolysaccharide-mediated signaling pathway
GO_0005576	Cellular component	extracellular region
GO_0140912	Molecular function	membrane destabilizing activity
GO_0001530	Molecular function	lipopolysaccharide binding
GO_0005515	Molecular function	protein binding

Gene name	DEFB118
Protein name	Beta-defensin Defensin beta 118 (Beta-defensin 18) (DEFB-18) (Epididymal secretory protein 13.6) (ESP13.6)
Synonyms	ESC42 C20orf63 DEFB18 hCG_1644909
Description	FUNCTION: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis . Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes . Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface . Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization . May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms . . FUNCTION: Has antibacterial activity. .
Accessions	ENST00000253381.3 A0A384MTK2 Q96PH6

DEFB118 report