DEFA6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEFA6 at tissue level.

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0051673Biological processdisruption of plasma membrane integrity in another organism
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0031640Biological processkilling of cells of another organism
GO_0002227Biological processinnate immune response in mucosa
GO_0050832Biological processdefense response to fungus
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0019731Biological processantibacterial humoral response
GO_0005615Cellular componentextracellular space
GO_0005796Cellular componentGolgi lumen
GO_0005576Cellular componentextracellular region
GO_0030133Cellular componenttransport vesicle
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDEFA6
Protein nameDefensin-6 (Defensin, alpha 6)
SynonymsDEF6
DescriptionFUNCTION: Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium . After binding to bacterial surface proteins, undergoes ordered self-assembly to form fibril-like nanonets that surround and entangle bacteria and thereby prevent bacterial invasion across the epithelial barrier . Entangles and agglutinates Gram-negative bacteria, such as E.coli, S.typhimurium and Y.enterocolitica, and Gram-positive bacteria such as L.monocytogenes, thereby protecting the intestine against invasion by enteric bacterial pathogens . Blocks adhesion of C.albicans to intestinal epithelial cells and thereby suppresses fungal invasion of epithelial cells and biofilm formation . Under reducing conditions and in an acidic environment similar to the intestinal milieu, exhibits inhibitory activity against anaerobic bacteria such as B.adolescentis, L.acidophilus and B.breve, as well as B.longum and S.thermophilus, possibly by leading to alterations in bacterial cell envelope structures . The disulfide-linked oxidized form exhibits negligible antimicrobial activity against Gram-negative and Gram-positive bacteria, as compared to the enteric defensin DEFA5 . .

AccessionsENST00000646187.2
Q01524
ENST00000297436.3