DCST1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCST1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCST1 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0035036Biological processsperm-egg recognition
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0045087Biological processinnate immune response
GO_0002080Cellular componentacrosomal membrane
GO_0005886Cellular componentplasma membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDCST1
Protein nameDC-STAMP domain containing 1
E3 ubiquitin-protein ligase DCST1 (EC 2.3.2.27) (DC-STAMP domain-containing protein 1) (RING-type E3 ubiquitin transferase)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity). .

AccessionsENST00000423025.6 [Q5T197-3]
ENST00000525273.5
E9PJX3
ENST00000295542.6 [Q5T197-1]
ENST00000368419.2 [Q5T197-2]
Q5T197