DCLRE1B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCLRE1B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCLRE1B at tissue level.

III. Associated gene sets

GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0036297Biological processinterstrand cross-link repair
GO_0031848Biological processprotection from non-homologous end joining at telomere
GO_0031627Biological processtelomeric loop formation
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0016233Biological processtelomere capping
GO_0000723Biological processtelomere maintenance
GO_0031860Biological processtelomeric 3' overhang formation
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0042803Molecular functionprotein homodimerization activity
GO_0008409Molecular function5'-3' exonuclease activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0035312Molecular function5'-3' DNA exonuclease activity
GO_0008800Molecular functionbeta-lactamase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameDCLRE1B
Protein name5' exonuclease Apollo (EC 3.1.-.-) (Beta-lactamase DCLRE1B) (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) (SNMIB) (hSNM1B)
5' exonuclease Apollo (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B)
DNA cross-link repair 1B
SynonymsSNM1B
DescriptionFUNCTION: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin . Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) . .

AccessionsA0A3B3IT16
A0A3B3ITQ0
ENST00000466480.2
ENST00000650450.2
ENST00000648795.1
Q9H816
ENST00000650596.1