DCLK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0035556Biological processintracellular signal transduction
GO_0021766Biological processhippocampus development
GO_0034504Biological processprotein localization to nucleus
GO_0021860Biological processpyramidal neuron development
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0005856Cellular componentcytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0008017Molecular functionmicrotubule binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameDCLK2
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
Doublecortin like kinase 2
SynonymshCG_18043
DCK2
DCAMKL2
DCDC3B
DescriptionFUNCTION: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). .

AccessionsA0A0U1RR70
ENST00000635524.1
Q8N568
G5E9L9
ENST00000296550.12 [Q8N568-1]
ENST00000506325.5 [Q8N568-2]
A0A0U1RRD0
ENST00000411937.6
ENST00000302176.8 [Q8N568-3]
ENST00000634233.1