DCD report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DCD at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DCD at tissue level.

III. Associated gene sets

GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0050832Biological processdefense response to fungus
GO_0051873Biological processkilling by host of symbiont cells
GO_0006508Biological processproteolysis
GO_0042742Biological processdefense response to bacterium
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0008233Molecular functionpeptidase activity
GO_0005216Molecular functionmonoatomic ion channel activity
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDCD
Protein nameDermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]
SynonymsDSEP
AIDD
DescriptionFUNCTION: [DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization . The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes . Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival . Highly effective against E.coli, E.faecalis, S.aureus and C.albicans . Optimal pH and salt concentration resemble the conditions in sweat . Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues . .; FUNCTION: [Survival-promoting peptide]: Promotes survival of neurons and displays phosphatase activity . It may bind IgG . .

AccessionsENST00000456047.2 [P81605-2]
ENST00000293371.11 [P81605-1]
ENST00000546807.5 [P81605-3]
P81605