Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 24% ± 6% | |
| astrocyte | 4 studies | 30% ± 6% | |
| ciliated cell | 3 studies | 21% ± 3% | |
| GABAergic neuron | 3 studies | 38% ± 6% | |
| glutamatergic neuron | 3 studies | 46% ± 8% | |
| oligodendrocyte | 3 studies | 22% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 33% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2076.00 | 1445 / 1445 | 100% | 10.49 | 183 / 183 |
| prostate | 100% | 2164.93 | 245 / 245 | 100% | 19.91 | 502 / 502 |
| breast | 100% | 1672.66 | 459 / 459 | 100% | 12.14 | 1116 / 1118 |
| brain | 100% | 1599.47 | 2641 / 2642 | 100% | 9.94 | 704 / 705 |
| uterus | 100% | 1735.73 | 170 / 170 | 100% | 9.52 | 457 / 459 |
| thymus | 100% | 1663.00 | 653 / 653 | 100% | 9.94 | 602 / 605 |
| ovary | 100% | 1833.39 | 180 / 180 | 99% | 8.32 | 427 / 430 |
| bladder | 100% | 2350.10 | 21 / 21 | 99% | 8.79 | 498 / 504 |
| kidney | 100% | 2112.94 | 89 / 89 | 99% | 9.55 | 890 / 901 |
| pancreas | 100% | 1279.42 | 327 / 328 | 99% | 7.24 | 176 / 178 |
| liver | 100% | 2603.53 | 226 / 226 | 98% | 8.21 | 399 / 406 |
| lung | 98% | 1376.66 | 565 / 578 | 100% | 9.30 | 1154 / 1155 |
| stomach | 100% | 2400.23 | 359 / 359 | 97% | 7.34 | 278 / 286 |
| intestine | 100% | 1855.26 | 966 / 966 | 97% | 6.65 | 512 / 527 |
| adrenal gland | 100% | 2835.47 | 258 / 258 | 90% | 4.91 | 206 / 230 |
| skin | 100% | 1846.48 | 1809 / 1809 | 89% | 7.42 | 422 / 472 |
| adipose | 100% | 1681.55 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2220.09 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 990.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 11.52 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.75 | 1 / 1 |
| blood vessel | 100% | 1873.41 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 2186.35 | 840 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 4.45 | 25 / 29 |
| eye | 0% | 0 | 0 / 0 | 57% | 2.80 | 46 / 80 |
| peripheral blood | 38% | 585.25 | 355 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0009083 | Biological process | branched-chain amino acid catabolic process |
| GO_0045252 | Cellular component | oxoglutarate dehydrogenase complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0042645 | Cellular component | mitochondrial nucleoid |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0043754 | Molecular function | dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity |
| GO_0047101 | Molecular function | branched-chain alpha-keto acid dehydrogenase activity |
| GO_0016407 | Molecular function | acetyltransferase activity |
| GO_0031405 | Molecular function | lipoic acid binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DBT |
| Protein name | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) Dihydrolipoamide branched chain transacylase E2 |
| Synonyms | BCKDHE2 BCATE2 |
| Description | FUNCTION: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component. . |
| Accessions | ENST00000681617.1 A0A7P0Z494 P11182 Q5VVL7 ENST00000681780.1 A0A7P0T9W1 ENST00000370131.3 ENST00000370132.8 |
