DBF4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0010571Biological processpositive regulation of nuclear cell cycle DNA replication
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_1901987Biological processregulation of cell cycle phase transition
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031431Cellular componentDbf4-dependent protein kinase complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0030295Molecular functionprotein kinase activator activity
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameDBF4B
Protein nameProtein DBF4 homolog B (Activator of S phase kinase-like protein 1) (ASK-like protein 1) (Chiffon homolog B) (Dbf4-related factor 1)
DBF4 zinc finger B (cDNA FLJ61009, highly similar to Homo sapiens Dbf4-related factor 1 (DRF1), transcript variant 1, mRNA)
SynonymsDRF1
ASKL1
DescriptionFUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. .

AccessionsB4E099
Q8NFT6
ENST00000526924.5
ENST00000393547.6 [Q8NFT6-2]
ENST00000315005.8 [Q8NFT6-1]