DAZL report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DAZL at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DAZL at tissue level.

III. Associated gene sets

GO_0001556Biological processoocyte maturation
GO_0007283Biological processspermatogenesis
GO_0007147Biological processfemale meiosis II
GO_0007281Biological processgerm cell development
GO_0045836Biological processpositive regulation of meiotic nuclear division
GO_0045948Biological processpositive regulation of translational initiation
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0032991Cellular componentprotein-containing complex
GO_0005840Cellular componentribosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0008494Molecular functiontranslation activator activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDAZL
Protein nameDAZL
Deleted in azoospermia-like (DAZ homolog) (DAZ-like autosomal) (Deleted in azoospermia-like 1) (SPGY-like-autosomal)
Deleted in azoospermia like
Deleted in azoospermia-like, isoform CRA_a (Testis secretory sperm-binding protein Li 204a)
SynonymsDAZLA
DAZL1
DAZH
SPGYLA
hCG_26763
DescriptionFUNCTION: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). .

AccessionsENST00000454457.1
ENST00000250863.12 [Q92904-2]
Q92904
A0SWV8
A0A140VK77
E7EV40
ENST00000399444.7 [Q92904-1]