CYP3A5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	9 studies	34% ± 13%	Explore
enterocyte	7 studies	45% ± 20%	Explore
hepatocyte	6 studies	73% ± 22%	Explore
goblet cell	5 studies	29% ± 12%	Explore
cholangiocyte	4 studies	77% ± 11%	Explore
capillary endothelial cell	4 studies	22% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	32% ± 7%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
secretory cell	3 studies	51% ± 3%	Explore
brush cell	3 studies	27% ± 10%	Explore
mucus secreting cell	3 studies	30% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
liver	4 studies	44% ± 15%	Explore
intestine	3 studies	24% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	23904.69	226 / 226	98%	84.95	399 / 406
pancreas	92%	6389.70	302 / 328	92%	43.29	163 / 178
stomach	76%	7299.26	274 / 359	94%	18.76	270 / 286
kidney	84%	1440.98	75 / 89	84%	15.77	760 / 901
intestine	55%	4795.76	527 / 966	95%	22.04	500 / 527
prostate	96%	5224.57	235 / 245	44%	3.06	220 / 502
adrenal gland	97%	2411.16	251 / 258	39%	5.28	89 / 230
lung	91%	1974.24	526 / 578	36%	5.46	415 / 1155
bladder	57%	1639.76	12 / 21	64%	11.26	322 / 504
esophagus	46%	1617.37	658 / 1445	68%	21.56	125 / 183
skin	72%	3805.33	1294 / 1809	11%	0.43	53 / 472
uterus	29%	314.71	50 / 170	34%	3.20	154 / 459
breast	51%	1182.95	234 / 459	8%	0.39	89 / 1118
adipose	29%	503.36	354 / 1204	0%	0	0 / 0
brain	0%	0.47	2 / 2642	27%	1.25	189 / 705
ovary	3%	22.58	5 / 180	17%	1.08	74 / 430
tonsil	0%	0	0 / 0	16%	0.84	7 / 45
thymus	0%	1.04	1 / 653	4%	0.32	27 / 605
muscle	4%	52.64	29 / 803	0%	0	0 / 0
blood vessel	1%	6.75	10 / 1335	0%	0	0 / 0
spleen	0%	34.96	1 / 241	0%	0	0 / 0
peripheral blood	0%	0.69	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006805	Biological process	xenobiotic metabolic process
GO_0009822	Biological process	alkaloid catabolic process
GO_0042573	Biological process	retinoic acid metabolic process
GO_0042178	Biological process	xenobiotic catabolic process
GO_0046222	Biological process	aflatoxin metabolic process
GO_0042572	Biological process	retinol metabolic process
GO_0002933	Biological process	lipid hydroxylation
GO_0008210	Biological process	estrogen metabolic process
GO_0070989	Biological process	oxidative demethylation
GO_0008202	Biological process	steroid metabolic process
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0070330	Molecular function	aromatase activity
GO_0101020	Molecular function	estrogen 16-alpha-hydroxylase activity
GO_0019825	Molecular function	oxygen binding
GO_0016491	Molecular function	oxidoreductase activity
GO_0004497	Molecular function	monooxygenase activity
GO_0005506	Molecular function	iron ion binding
GO_0008401	Molecular function	retinoic acid 4-hydroxylase activity
GO_0020037	Molecular function	heme binding
GO_0050649	Molecular function	testosterone 6-beta-hydroxylase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYP3A5
Protein name	Alternative protein CYP3A5 Cytochrome P450 family 3 subfamily A member 5 Cytochrome P-450 Cytochrome P450 Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450-PCN3) Cytochrome P450 3A (EC 1.14.14.-)
Synonyms	DKFZp686I18188
Description	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds . Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 . Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione . Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) . Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance . Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine . . FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .
Accessions	Q96RK7 ENST00000439761.3 [P20815-2] Q96RK8 ENST00000456417.5 Q7Z446 ENST00000646887.1 [P20815-2] ENST00000222982.8 [P20815-1] P20815 Q96RK6 Q7Z3N0 Q14V85 L8EC58 Q7Z447

CYP3A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review