CYP3A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0008209Biological processandrogen metabolic process
GO_0036378Biological processcalcitriol biosynthetic process from calciol
GO_0008203Biological processcholesterol metabolic process
GO_0009822Biological processalkaloid catabolic process
GO_0016098Biological processmonoterpenoid metabolic process
GO_0042369Biological processvitamin D catabolic process
GO_0042573Biological processretinoic acid metabolic process
GO_0042359Biological processvitamin D metabolic process
GO_0042178Biological processxenobiotic catabolic process
GO_0046222Biological processaflatoxin metabolic process
GO_0042572Biological processretinol metabolic process
GO_0002933Biological processlipid hydroxylation
GO_0008210Biological processestrogen metabolic process
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0006706Biological processsteroid catabolic process
GO_0070989Biological processoxidative demethylation
GO_0006629Biological processlipid metabolic process
GO_0008202Biological processsteroid metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0019899Molecular functionenzyme binding
GO_0070330Molecular functionaromatase activity
GO_0062189Molecular functionanandamide 14,15 epoxidase activity
GO_0101020Molecular functionestrogen 16-alpha-hydroxylase activity
GO_0102320Molecular function1,8-cineole 2-exo-monooxygenase activity
GO_0019825Molecular functionoxygen binding
GO_0016491Molecular functionoxidoreductase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0008401Molecular functionretinoic acid 4-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0034875Molecular functioncaffeine oxidase activity
GO_0062187Molecular functionanandamide 8,9 epoxidase activity
GO_0005496Molecular functionsteroid binding
GO_0050649Molecular functiontestosterone 6-beta-hydroxylase activity
GO_0062181Molecular function1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
GO_0030343Molecular functionvitamin D3 25-hydroxylase activity
GO_0008395Molecular functionsteroid hydroxylase activity
GO_0050591Molecular functionquinine 3-monooxygenase activity
GO_0005515Molecular functionprotein binding
GO_0062188Molecular functionanandamide 11,12 epoxidase activity
GO_0070576Molecular functionvitamin D 24-hydroxylase activity
GO_0101021Molecular functionestrogen 2-hydroxylase activity

IV. Literature review

[source]
Gene nameCYP3A4
Protein nameCytochrome P450 3A4 (EC 1.14.14.1) (1,4-cineole 2-exo-monooxygenase) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55)
Cytochrome P450 family 3 subfamily A member 4
Cytochrome P450 3A (EC 1.14.14.-)
SynonymsCYP3A3
tcag7.603
hCG_17094
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds . Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position . Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone . Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones . Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis . Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) . Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond . Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Plays a role in the metabolism of retinoids. Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) . Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance . Responsible for oxidative metabolism of xenobiotics. Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) . Metabolizes the majority of the administered drugs. Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole . Hydroxylates antimalarial drug quinine . Acts as a 1,4-cineole 2-exo-monooxygenase . Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) . .

FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .

FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .

FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .

AccessionsA0A499FJM4
P08684
Q7Z448
ENST00000651514.1
ENST00000415003.1
ENST00000336411.7
Q6GRK0
ENST00000652018.1
E7EVM8
C9JBD2
ENST00000354593.6
A0A494C0W7