CYP2S1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP2S1 at tissue level.

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0006690Biological processicosanoid metabolic process
GO_0042573Biological processretinoic acid metabolic process
GO_1903604Biological processcytochrome metabolic process
GO_0019373Biological processepoxygenase P450 pathway
GO_0006693Biological processprostaglandin metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO_0004796Molecular functionthromboxane-A synthase activity
GO_0036134Molecular function12-hydroxyheptadecatrienoic acid synthase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0008401Molecular functionretinoic acid 4-hydroxylase activity
GO_0020037Molecular functionheme binding
GO_0106256Molecular functionhydroperoxy icosatetraenoate dehydratase activity
GO_0008392Molecular functionarachidonic acid epoxygenase activity
GO_0016836Molecular functionhydro-lyase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCYP2S1
Protein nameCytochrome P450 2S1 (EC 1.14.14.-) (CYPIIS1) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Thromboxane-A synthase) (EC 5.3.99.5)
Cytochrome P450 family 2 subfamily S member 1
SynonymsUNQ891/PRO1906
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids . In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) . Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage . .

AccessionsENST00000600561.1
ENST00000310054.9 [Q96SQ9-1]
ENST00000593890.1
M0R2G8
M0R152
M0R057
ENST00000595590.1
ENST00000593545.5
Q96SQ9
M0QYI2
M0QY51
ENST00000597754.1