CYP27B1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP27B1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP27B1 at tissue level.

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0070314Biological processG1 to G0 transition
GO_0006766Biological processvitamin metabolic process
GO_0036378Biological processcalcitriol biosynthetic process from calciol
GO_0043627Biological processresponse to estrogen
GO_0046697Biological processdecidualization
GO_0010956Biological processnegative regulation of calcidiol 1-monooxygenase activity
GO_0070564Biological processpositive regulation of vitamin D receptor signaling pathway
GO_0030500Biological processregulation of bone mineralization
GO_0042369Biological processvitamin D catabolic process
GO_0010980Biological processpositive regulation of vitamin D 24-hydroxylase activity
GO_0034341Biological processresponse to type II interferon
GO_0042359Biological processvitamin D metabolic process
GO_0030282Biological processbone mineralization
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0006816Biological processcalcium ion transport
GO_0033280Biological processresponse to vitamin D
GO_0032496Biological processresponse to lipopolysaccharide
GO_0030308Biological processnegative regulation of cell growth
GO_0005739Cellular componentmitochondrion
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0004498Molecular functioncalcidiol 1-monooxygenase activity
GO_0062185Molecular functionsecalciferol 1-monooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding

IV. Literature review

[source]
Gene nameCYP27B1
Protein name25-hydroxyvitamin D3-1alpha-hydroxylase (Cytochrome P450, family 27, subfamily B, polypeptide 1)
Cytochrome P450 family 27 subfamily B member 1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.15.18) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Calcidiol 1-monooxygenase) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha) (Cytochrome p450 27B1)
SynonymsCYP27B
CYP1ALPHA
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) . Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway . Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin . .

AccessionsQ9UP42
ENST00000228606.9
O15528
V9GYP0
ENST00000546609.1
ENST00000546567.5
F8VWR7