CYP1A2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP1A2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP1A2 at tissue level.

III. Associated gene sets

GO_0009403Biological processtoxin biosynthetic process
GO_0010468Biological processregulation of gene expression
GO_0030324Biological processlung development
GO_0006805Biological processxenobiotic metabolic process
GO_0009791Biological processpost-embryonic development
GO_0032259Biological processmethylation
GO_0008203Biological processcholesterol metabolic process
GO_0071276Biological processcellular response to cadmium ion
GO_0045333Biological processcellular respiration
GO_0016098Biological processmonoterpenoid metabolic process
GO_0006778Biological processporphyrin-containing compound metabolic process
GO_0097267Biological processomega-hydroxylase P450 pathway
GO_0009820Biological processalkaloid metabolic process
GO_0019373Biological processepoxygenase P450 pathway
GO_0042178Biological processxenobiotic catabolic process
GO_0046222Biological processaflatoxin metabolic process
GO_0050665Biological processhydrogen peroxide biosynthetic process
GO_0042572Biological processretinol metabolic process
GO_0008210Biological processestrogen metabolic process
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0006706Biological processsteroid catabolic process
GO_0070989Biological processoxidative demethylation
GO_0032787Biological processmonocarboxylic acid metabolic process
GO_0018894Biological processdibenzo-p-dioxin metabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0019899Molecular functionenzyme binding
GO_0032451Molecular functiondemethylase activity
GO_0070330Molecular functionaromatase activity
GO_0009055Molecular functionelectron transfer activity
GO_0016712Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO_0101020Molecular functionestrogen 16-alpha-hydroxylase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0004497Molecular functionmonooxygenase activity
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0034875Molecular functioncaffeine oxidase activity
GO_0106256Molecular functionhydroperoxy icosatetraenoate dehydratase activity
GO_0005515Molecular functionprotein binding
GO_0101021Molecular functionestrogen 2-hydroxylase activity

IV. Literature review

[source]
Gene nameCYP1A2
Protein nameCytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
Synonyms
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds . Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 . Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis . May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid . Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer . Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA . May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) . Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin . Metabolizes caffeine via N3-demethylation (Probable). .

AccessionsENST00000343932.5
P05177