CYP17A1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CYP17A1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CYP17A1 at tissue level.

III. Associated gene sets

GO_0042448Biological processprogesterone metabolic process
GO_0042446Biological processhormone biosynthetic process
GO_0006704Biological processglucocorticoid biosynthetic process
GO_0008202Biological processsteroid metabolic process
GO_0006702Biological processandrogen biosynthetic process
GO_0007548Biological processsex differentiation
GO_0006694Biological processsteroid biosynthetic process
GO_0030424Cellular componentaxon
GO_0005783Cellular componentendoplasmic reticulum
GO_0043025Cellular componentneuronal cell body
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0019825Molecular functionoxygen binding
GO_0005506Molecular functioniron ion binding
GO_0020037Molecular functionheme binding
GO_0004508Molecular functionsteroid 17-alpha-monooxygenase activity

IV. Literature review

[source]
Gene nameCYP17A1
Protein nameSteroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Steroid 17-alpha-monooxygenase)
Steroid 17-alpha-monooxygenase
Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.99.9)
Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
SynonymsCYP17
hCG_22577
S17AH
DescriptionFUNCTION: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis . Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione . Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA . Also 16-alpha hydroxylates androgens, relevant for estriol synthesis . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) . .

AccessionsENST00000638272.1
A0A1W2PRK7
ENST00000639393.1
ENST00000638190.1
A0A1W2PRY0
P05093
A0A1L7H7S6
C7F7K7
ENST00000369887.4
A0A1W2PQT5
A0A1L7H7K7
Q1HB44
A0A1W2PQ28
ENST00000638971.1
A0A1L7H7L1