CUL7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CUL7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CUL7 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0001837Biological processepithelial to mesenchymal transition
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0001570Biological processvasculogenesis
GO_0000281Biological processmitotic cytokinesis
GO_0001890Biological processplacenta development
GO_0007030Biological processGolgi organization
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0006508Biological processproteolysis
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005680Cellular componentanaphase-promoting complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_1990393Cellular component3M complex
GO_0005813Cellular componentcentrosome
GO_0005794Cellular componentGolgi apparatus
GO_0031467Cellular componentCul7-RING ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCUL7
Protein nameCullin 7
Cullin-7 (CUL-7)
Alternative protein CUL7
SynonymsKIAA0076
DescriptionFUNCTION: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer . Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 . Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 . Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain . Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) . The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation . Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development . Does not promote polyubiquitination and proteasomal degradation of p53/TP53 . While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions. .

AccessionsA0A8I5KW87
Q14999
ENST00000674134.1
ENST00000265348.9 [Q14999-1]
ENST00000673725.1
ENST00000688707.1
A0A8I5KQF0
ENST00000692002.1
A0A669KBH4
ENST00000687225.1
A0A669KAU7
A0A8I5KS45
A0A669KB95
L8E835
ENST00000685042.1
A0A8I5KUS3
ENST00000674112.2
ENST00000674100.1
ENST00000690231.1 [Q14999-1]