CTH report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CTH at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTH at tissue level.

III. Associated gene sets

GO_0018272Biological processprotein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO_0019346Biological processtranssulfuration
GO_0006534Biological processcysteine metabolic process
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0019344Biological processcysteine biosynthetic process
GO_0019343Biological processcysteine biosynthetic process via cystathionine
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070814Biological processhydrogen sulfide biosynthetic process
GO_0044524Biological processprotein sulfhydration
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_1904831Biological processpositive regulation of aortic smooth muscle cell differentiation
GO_0006629Biological processlipid metabolic process
GO_0051289Biological processprotein homotetramerization
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0044540Molecular functionL-cystine L-cysteine-lyase (deaminating)
GO_0004123Molecular functioncystathionine gamma-lyase activity
GO_0042802Molecular functionidentical protein binding
GO_0080146Molecular functionL-cysteine desulfhydrase activity
GO_0047982Molecular functionhomocysteine desulfhydrase activity
GO_0098606Molecular functionselenocystathionine gamma-lyase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTH
Protein nameCystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2)
Synonyms
DescriptionFUNCTION: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate . Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione . Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce the endogenous gaseous signaling molecule hydrogen sulfide (H2S) . In vitro, it converts two L-cysteine molecules into lanthionine and H2S, also two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia (which is a risk factor for cardiovascular disease, diabetes, and Alzheimer's disease) . Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively . Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function . By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (Probable) . Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). .

AccessionsP32929
ENST00000411986.6 [P32929-3]
ENST00000346806.2 [P32929-2]
ENST00000370938.8 [P32929-1]