CTDSP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0006470Biological processprotein dephosphorylation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0008420Molecular functionRNA polymerase II CTD heptapeptide repeat phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCTDSP2
Protein nameCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2)
CTD small phosphatase 2
SynonymsOS4
NIF2
SCP2
DescriptionFUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. .

AccessionsF8W184
F8VYL0
H0YI29
O14595
ENST00000551594.1
H0YI12
ENST00000549039.5
ENST00000547701.5
ENST00000548823.1
ENST00000398073.7
ENST00000550144.1
F8W1I1