Name | Number of supported studies | Average coverage | |
---|---|---|---|
GABAergic neuron | 3 studies | 19% ± 4% | |
glutamatergic neuron | 3 studies | 24% ± 8% |
Insufficient scRNA-seq data for expression of CTC1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3257.67 | 1445 / 1445 | 100% | 11.36 | 183 / 183 |
thymus | 100% | 4414.15 | 653 / 653 | 100% | 18.31 | 604 / 605 |
intestine | 100% | 4212.16 | 966 / 966 | 100% | 8.84 | 526 / 527 |
prostate | 100% | 3603.16 | 245 / 245 | 100% | 10.90 | 501 / 502 |
stomach | 100% | 2857.22 | 359 / 359 | 100% | 9.26 | 285 / 286 |
lung | 100% | 3975.59 | 578 / 578 | 99% | 11.05 | 1149 / 1155 |
breast | 100% | 3815.15 | 459 / 459 | 99% | 16.24 | 1110 / 1118 |
uterus | 100% | 4521.15 | 170 / 170 | 99% | 8.67 | 455 / 459 |
kidney | 100% | 3007.44 | 89 / 89 | 98% | 10.73 | 887 / 901 |
bladder | 100% | 3315.14 | 21 / 21 | 98% | 7.85 | 496 / 504 |
pancreas | 100% | 2244.17 | 328 / 328 | 98% | 9.74 | 175 / 178 |
ovary | 100% | 4387.79 | 180 / 180 | 97% | 7.80 | 419 / 430 |
skin | 96% | 1982.19 | 1743 / 1809 | 99% | 9.62 | 467 / 472 |
adrenal gland | 100% | 2191.06 | 258 / 258 | 95% | 7.50 | 218 / 230 |
brain | 95% | 2427.66 | 2505 / 2642 | 100% | 12.72 | 704 / 705 |
liver | 100% | 1550.46 | 225 / 226 | 89% | 5.20 | 360 / 406 |
adipose | 100% | 2808.02 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3071.68 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 16.00 | 29 / 29 |
spleen | 100% | 7398.31 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 10.06 | 45 / 45 |
eye | 0% | 0 | 0 / 0 | 99% | 7.46 | 79 / 80 |
peripheral blood | 99% | 3841.05 | 916 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 1363.29 | 846 / 861 | 0% | 0 | 0 / 0 |
muscle | 89% | 933.84 | 714 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
GO_0010833 | Biological process | telomere maintenance via telomere lengthening |
GO_0048539 | Biological process | bone marrow development |
GO_0006974 | Biological process | DNA damage response |
GO_0035264 | Biological process | multicellular organism growth |
GO_0090399 | Biological process | replicative senescence |
GO_0010389 | Biological process | regulation of G2/M transition of mitotic cell cycle |
GO_0071425 | Biological process | hematopoietic stem cell proliferation |
GO_0048536 | Biological process | spleen development |
GO_0032211 | Biological process | negative regulation of telomere maintenance via telomerase |
GO_0016233 | Biological process | telomere capping |
GO_0045740 | Biological process | positive regulation of DNA replication |
GO_0048538 | Biological process | thymus development |
GO_0000723 | Biological process | telomere maintenance |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_1990879 | Cellular component | CST complex |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0005634 | Cellular component | nucleus |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0042162 | Molecular function | telomeric DNA binding |
GO_0098505 | Molecular function | G-rich strand telomeric DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CTC1 |
Protein name | CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) CST complex subunit CTC1 |
Synonyms | C17orf68 |
Description | FUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation . However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha . The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins . Involved in telomere maintenance . Involved in genome stability . May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity). . |
Accessions | ENST00000699858.1 A0A8V8TNY5 A0A8V8TP86 A0A8V8TQP4 ENST00000699852.1 ENST00000699856.1 J3KSR1 ENST00000643543.1 A0A8V8TQB6 A0A8V8TQN9 ENST00000578537.1 ENST00000449476.7 [Q2NKJ3-2] ENST00000699853.1 A0A2R8Y574 J3KSZ1 ENST00000580299.2 ENST00000699859.1 Q2NKJ3 D3U719 ENST00000651323.1 [Q2NKJ3-1] ENST00000699849.1 ENST00000581729.2 J3QKT7 |