CTC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTC1 at tissue level.

III. Associated gene sets

GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0010833Biological processtelomere maintenance via telomere lengthening
GO_0048539Biological processbone marrow development
GO_0006974Biological processDNA damage response
GO_0035264Biological processmulticellular organism growth
GO_0090399Biological processreplicative senescence
GO_0010389Biological processregulation of G2/M transition of mitotic cell cycle
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0048536Biological processspleen development
GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0016233Biological processtelomere capping
GO_0045740Biological processpositive regulation of DNA replication
GO_0048538Biological processthymus development
GO_0000723Biological processtelomere maintenance
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_1990879Cellular componentCST complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTC1
Protein nameCST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B)
CST complex subunit CTC1
SynonymsC17orf68
DescriptionFUNCTION: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation . However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha . The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins . Involved in telomere maintenance . Involved in genome stability . May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity). .

AccessionsENST00000699858.1
A0A8V8TNY5
A0A8V8TP86
A0A8V8TQP4
ENST00000699852.1
ENST00000699856.1
J3KSR1
ENST00000643543.1
A0A8V8TQB6
A0A8V8TQN9
ENST00000578537.1
ENST00000449476.7 [Q2NKJ3-2]
ENST00000699853.1
A0A2R8Y574
J3KSZ1
ENST00000580299.2
ENST00000699859.1
Q2NKJ3
D3U719
ENST00000651323.1 [Q2NKJ3-1]
ENST00000699849.1
ENST00000581729.2
J3QKT7