Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 24% ± 7% | |
| oligodendrocyte | 6 studies | 22% ± 5% | |
| epithelial cell | 5 studies | 30% ± 8% | |
| GABAergic neuron | 4 studies | 33% ± 10% | |
| glutamatergic neuron | 4 studies | 40% ± 12% | |
| astrocyte | 4 studies | 21% ± 5% | |
| microglial cell | 3 studies | 19% ± 0% | |
| erythroblast | 3 studies | 29% ± 11% | |
| oligodendrocyte precursor cell | 3 studies | 25% ± 1% | |
| endothelial cell of lymphatic vessel | 3 studies | 18% ± 3% | |
| macrophage | 3 studies | 22% ± 4% | |
| transit amplifying cell | 3 studies | 41% ± 17% | |
| interneuron | 3 studies | 34% ± 16% | |
| neuron | 3 studies | 27% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 3712.27 | 459 / 459 | 100% | 164.67 | 1118 / 1118 |
| esophagus | 100% | 4085.35 | 1445 / 1445 | 100% | 177.22 | 183 / 183 |
| lung | 100% | 3227.81 | 578 / 578 | 100% | 123.22 | 1155 / 1155 |
| ovary | 100% | 3599.98 | 180 / 180 | 100% | 134.99 | 430 / 430 |
| stomach | 100% | 2909.98 | 359 / 359 | 100% | 163.26 | 286 / 286 |
| uterus | 100% | 4208.65 | 170 / 170 | 100% | 160.20 | 459 / 459 |
| bladder | 100% | 3821.29 | 21 / 21 | 100% | 141.00 | 503 / 504 |
| intestine | 100% | 3371.07 | 966 / 966 | 100% | 155.80 | 525 / 527 |
| brain | 100% | 3119.49 | 2631 / 2642 | 100% | 85.31 | 705 / 705 |
| prostate | 100% | 3077.30 | 245 / 245 | 99% | 83.33 | 499 / 502 |
| thymus | 100% | 3074.86 | 653 / 653 | 99% | 66.30 | 599 / 605 |
| skin | 100% | 6285.30 | 1809 / 1809 | 99% | 127.80 | 465 / 472 |
| pancreas | 99% | 1922.32 | 325 / 328 | 98% | 68.26 | 175 / 178 |
| adrenal gland | 100% | 3491.88 | 258 / 258 | 96% | 64.28 | 220 / 230 |
| kidney | 100% | 2540.33 | 89 / 89 | 95% | 58.65 | 860 / 901 |
| liver | 100% | 1829.39 | 225 / 226 | 94% | 55.90 | 383 / 406 |
| adipose | 100% | 3627.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3134.08 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 99.34 | 29 / 29 |
| muscle | 100% | 4159.17 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3320.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 148.16 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 59.73 | 1 / 1 |
| heart | 96% | 2363.32 | 823 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 68.41 | 76 / 80 |
| peripheral blood | 72% | 2804.87 | 669 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006611 | Biological process | protein export from nucleus |
| GO_0006606 | Biological process | protein import into nucleus |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005635 | Cellular component | nuclear envelope |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005049 | Molecular function | nuclear export signal receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| Gene name | CSE1L |
| Protein name | Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) |
| Synonyms | CAS XPO2 |
| Description | FUNCTION: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. . |
| Accessions | ENST00000396192.7 [P55060-4] P55060 ENST00000262982.3 [P55060-1] |