Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 10 studies | 27% ± 10% | |
| classical monocyte | 9 studies | 21% ± 8% | |
| B cell | 5 studies | 18% ± 2% | |
| memory B cell | 4 studies | 21% ± 3% | |
| monocyte | 4 studies | 26% ± 12% | |
| neutrophil | 3 studies | 24% ± 6% | |
| non-classical monocyte | 3 studies | 16% ± 1% | |
| podocyte | 3 studies | 59% ± 16% |
Insufficient scRNA-seq data for expression of CR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 98% | 1061.53 | 567 / 578 | 54% | 1.52 | 620 / 1155 |
| kidney | 89% | 534.73 | 79 / 89 | 27% | 0.70 | 247 / 901 |
| spleen | 100% | 7133.53 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 8253.71 | 927 / 929 | 0% | 0 | 0 / 0 |
| intestine | 74% | 473.43 | 717 / 966 | 21% | 0.61 | 111 / 527 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 5.92 | 27 / 29 |
| adipose | 92% | 748.29 | 1110 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 62% | 165.62 | 13 / 21 | 19% | 0.68 | 98 / 504 |
| breast | 64% | 195.53 | 296 / 459 | 15% | 0.35 | 171 / 1118 |
| stomach | 41% | 141.65 | 148 / 359 | 31% | 0.84 | 89 / 286 |
| esophagus | 47% | 143.54 | 684 / 1445 | 17% | 0.42 | 32 / 183 |
| adrenal gland | 57% | 156.87 | 146 / 258 | 4% | 0.17 | 9 / 230 |
| liver | 46% | 126.20 | 104 / 226 | 8% | 0.20 | 31 / 406 |
| pancreas | 6% | 12.23 | 19 / 328 | 43% | 1.40 | 76 / 178 |
| blood vessel | 44% | 182.00 | 592 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 19% | 48.81 | 35 / 180 | 19% | 0.39 | 80 / 430 |
| thymus | 28% | 77.31 | 185 / 653 | 9% | 0.23 | 57 / 605 |
| skin | 6% | 9.64 | 100 / 1809 | 31% | 1.12 | 147 / 472 |
| heart | 36% | 94.07 | 313 / 861 | 0% | 0 | 0 / 0 |
| uterus | 23% | 56.05 | 39 / 170 | 8% | 0.24 | 38 / 459 |
| prostate | 24% | 53.78 | 58 / 245 | 5% | 0.08 | 25 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 0.48 | 11 / 45 |
| brain | 7% | 12.80 | 189 / 2642 | 6% | 0.33 | 44 / 705 |
| muscle | 8% | 13.42 | 64 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006957 | Biological process | complement activation, alternative pathway |
| GO_0032703 | Biological process | negative regulation of interleukin-2 production |
| GO_0001971 | Biological process | negative regulation of activation of membrane attack complex |
| GO_0045916 | Biological process | negative regulation of complement activation |
| GO_0045957 | Biological process | negative regulation of complement activation, alternative pathway |
| GO_0002435 | Biological process | immune complex clearance by erythrocytes |
| GO_0045959 | Biological process | negative regulation of complement activation, classical pathway |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0002638 | Biological process | negative regulation of immunoglobulin production |
| GO_0001970 | Biological process | positive regulation of activation of membrane attack complex |
| GO_0006958 | Biological process | complement activation, classical pathway |
| GO_1903660 | Biological process | negative regulation of complement-dependent cytotoxicity |
| GO_0042130 | Biological process | negative regulation of T cell proliferation |
| GO_1900005 | Biological process | positive regulation of serine-type endopeptidase activity |
| GO_0007009 | Biological process | plasma membrane organization |
| GO_0032689 | Biological process | negative regulation of type II interferon production |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_1900004 | Biological process | negative regulation of serine-type endopeptidase activity |
| GO_0002456 | Biological process | T cell mediated immunity |
| GO_0045591 | Biological process | positive regulation of regulatory T cell differentiation |
| GO_1900099 | Biological process | negative regulation of plasma cell differentiation |
| GO_1904669 | Biological process | ATP export |
| GO_0002430 | Biological process | complement receptor mediated signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0044853 | Cellular component | plasma membrane raft |
| GO_0009986 | Cellular component | cell surface |
| GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
| GO_0001861 | Molecular function | complement component C4b receptor activity |
| GO_0001855 | Molecular function | complement component C4b binding |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0004877 | Molecular function | complement component C3b receptor activity |
| GO_0001851 | Molecular function | complement component C3b binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CR1 |
| Protein name | Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35) CR1 protein domain SCR25 Complement receptor 1 Complement component (3b/4b) receptor 1 (Knops blood group) Complement C3b/C4b receptor 1 (Knops blood group) Complement receptor type 1 |
| Synonyms | C3BR |
| Description | FUNCTION: Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages . Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation . Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d . Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells . .; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus. . |
| Accessions | Q9HB99 H0YE06 Q5SBK0 Q5SBJ5 A0A346RCT4 ENST00000367053.6 Q5SBK2 ENST00000367052.6 Q5SR44 A0A346RD54 A0A346RD80 Q9HB98 P17927 Q5SBJ6 V6EYC3 A0A346RD63 Q5SBJ9 ENST00000367051.6 E9PDY4 ENST00000534202.5 ENST00000529814.1 Q5SBK6 Q5SBJ8 A0A2S1GUW1 ENST00000400960.7 Q5SBK3 E9PQN4 Q9HC55 Q5SBK5 A0A2S1GUW8 ENST00000367049.9 Q5SBJ7 A0A346RD82 Q5SBK1 Q9HC54 Q5SBK4 |
