I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 3 studies | 23% ± 6% | |
| epithelial cell | 3 studies | 27% ± 8% | |
| dendritic cell | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 3 studies | 23% ± 6% | |
| epithelial cell | 3 studies | 27% ± 8% | |
| dendritic cell | 3 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of CPSF1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 6168.48 | 1445 / 1445 | 100% | 76.98 | 183 / 183 |
| ovary | 100% | 9146.31 | 180 / 180 | 100% | 96.01 | 430 / 430 |
| pancreas | 100% | 6635.57 | 328 / 328 | 100% | 59.23 | 178 / 178 |
| uterus | 100% | 9470.88 | 170 / 170 | 100% | 72.28 | 458 / 459 |
| stomach | 100% | 7230.22 | 359 / 359 | 100% | 77.74 | 285 / 286 |
| intestine | 100% | 8753.10 | 966 / 966 | 100% | 79.31 | 525 / 527 |
| prostate | 100% | 10170.89 | 245 / 245 | 100% | 54.14 | 500 / 502 |
| skin | 100% | 7510.16 | 1809 / 1809 | 99% | 70.37 | 469 / 472 |
| thymus | 100% | 9626.95 | 653 / 653 | 99% | 57.22 | 600 / 605 |
| lung | 100% | 7549.42 | 577 / 578 | 99% | 59.76 | 1145 / 1155 |
| breast | 100% | 7877.41 | 459 / 459 | 99% | 61.05 | 1105 / 1118 |
| bladder | 100% | 6835.95 | 21 / 21 | 99% | 69.52 | 498 / 504 |
| liver | 100% | 4651.85 | 226 / 226 | 98% | 42.63 | 399 / 406 |
| adrenal gland | 100% | 6754.67 | 258 / 258 | 98% | 41.70 | 225 / 230 |
| kidney | 100% | 6172.34 | 89 / 89 | 97% | 34.04 | 873 / 901 |
| brain | 96% | 5130.52 | 2548 / 2642 | 99% | 54.51 | 700 / 705 |
| adipose | 100% | 6276.03 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 81.91 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 82.43 | 29 / 29 |
| spleen | 100% | 10831.56 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 62.75 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 69.52 | 1 / 1 |
| blood vessel | 100% | 6098.87 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 3685.35 | 792 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 3432.44 | 833 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 94% | 4707.12 | 875 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006397 | Biological process | mRNA processing |
| GO_0180012 | Biological process | co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway |
| GO_0005847 | Cellular component | mRNA cleavage and polyadenylation specificity factor complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0035925 | Molecular function | mRNA 3'-UTR AU-rich region binding |
| Gene name | CPSF1 |
| Protein name | Cleavage and polyadenylation specific factor 1 Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) |
| Synonyms | CPSF160 |
| Description | FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction . May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity). . |
| Accessions | ENST00000644539.2 ENST00000643746.1 Q10570 ENST00000532935.5 ENST00000616140.2 ENST00000620219.4 E9PIM1 A0A087X101 ENST00000531727.5 A0A087WTV4 ENST00000531042.5 |
