CPLX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0046928Biological processregulation of neurotransmitter secretion
GO_0043195Cellular componentterminal bouton
GO_0031201Cellular componentSNARE complex
GO_0005886Cellular componentplasma membrane
GO_0000149Molecular functionSNARE binding
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameCPLX4
Protein nameComplexin 4
Complexin-4 (Complexin IV) (CPX IV)
SynonymshCG_1776479
DescriptionFUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). .

AccessionsK7EM04
Q7Z7G2
ENST00000587244.5
ENST00000299721.3