CP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098869Biological processcellular oxidant detoxification
GO_0006825Biological processcopper ion transport
GO_0006826Biological processiron ion transport
GO_0006879Biological processintracellular iron ion homeostasis
GO_0006878Biological processintracellular copper ion homeostasis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0072562Cellular componentblood microparticle
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005765Cellular componentlysosomal membrane
GO_0004322Molecular functionferroxidase activity
GO_0047066Molecular functionphospholipid-hydroperoxide glutathione peroxidase activity
GO_0004602Molecular functionglutathione peroxidase activity
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0016491Molecular functionoxidoreductase activity
GO_0016724Molecular functionoxidoreductase activity, acting on metal ions, oxygen as acceptor
GO_0005507Molecular functioncopper ion binding

IV. Literature review

[source]
Gene nameCP
Protein nameCP protein
Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1)
ferroxidase (EC 1.16.3.1)
Ceruloplasmin
SynonymshCG_1781201
DescriptionFUNCTION: Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane . Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin . Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1 (By similarity). Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols . Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis . .

AccessionsENST00000479771.5
ENST00000494544.1
ENST00000455472.3
ENST00000481169.5
D6RE86
E9PFZ2
H7C5N5
Q6NSB2
P00450
A5PL27
ENST00000264613.11
H7C5R1