I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 4 studies | 17% ± 2% | |
| epithelial cell | 4 studies | 28% ± 8% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 4 studies | 17% ± 2% | |
| epithelial cell | 4 studies | 28% ± 8% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 4% |
Insufficient scRNA-seq data for expression of COQ7 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 1059.37 | 89 / 89 | 100% | 21.13 | 901 / 901 |
| ovary | 100% | 1544.38 | 180 / 180 | 100% | 15.45 | 430 / 430 |
| prostate | 100% | 1352.64 | 245 / 245 | 100% | 35.60 | 502 / 502 |
| stomach | 100% | 984.70 | 359 / 359 | 100% | 13.70 | 286 / 286 |
| breast | 100% | 1014.97 | 459 / 459 | 100% | 27.19 | 1117 / 1118 |
| brain | 100% | 845.99 | 2638 / 2642 | 100% | 21.33 | 705 / 705 |
| thymus | 100% | 1240.82 | 653 / 653 | 100% | 20.94 | 604 / 605 |
| bladder | 100% | 1146.43 | 21 / 21 | 100% | 15.43 | 502 / 504 |
| lung | 100% | 778.82 | 577 / 578 | 100% | 14.35 | 1152 / 1155 |
| uterus | 100% | 1356.38 | 170 / 170 | 100% | 16.61 | 457 / 459 |
| pancreas | 100% | 569.37 | 327 / 328 | 99% | 13.43 | 177 / 178 |
| adrenal gland | 100% | 1234.85 | 258 / 258 | 99% | 16.82 | 228 / 230 |
| intestine | 100% | 1234.54 | 966 / 966 | 99% | 15.37 | 522 / 527 |
| esophagus | 100% | 1113.00 | 1445 / 1445 | 99% | 11.30 | 181 / 183 |
| liver | 100% | 482.85 | 226 / 226 | 99% | 9.87 | 400 / 406 |
| skin | 100% | 775.07 | 1809 / 1809 | 98% | 15.01 | 463 / 472 |
| adipose | 100% | 898.25 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1041.92 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 10.50 | 29 / 29 |
| muscle | 100% | 1441.48 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 795.48 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.28 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.93 | 1 / 1 |
| heart | 99% | 1059.76 | 851 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 15.94 | 78 / 80 |
| peripheral blood | 74% | 399.70 | 687 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_2000377 | Biological process | regulation of reactive oxygen species metabolic process |
| GO_0006744 | Biological process | ubiquinone biosynthetic process |
| GO_0008340 | Biological process | determination of adult lifespan |
| GO_0031314 | Cellular component | extrinsic component of mitochondrial inner membrane |
| GO_0110142 | Cellular component | ubiquinone biosynthesis complex |
| GO_0005694 | Cellular component | chromosome |
| GO_0005743 | Cellular component | mitochondrial inner membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0016709 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO_0008682 | Molecular function | 3-demethoxyubiquinol 3-hydroxylase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | COQ7 |
| Protein name | Coenzyme Q7 homolog, ubiquinone (Yeast), isoform CRA_b (Coenzyme Q7, hydroxylase) 5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.99.60) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7) Coenzyme Q7, hydroxylase |
| Synonyms | hCG_1743024 |
| Description | FUNCTION: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (By similarity). Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis . . FUNCTION: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. . FUNCTION: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. . FUNCTION: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. . |
| Accessions | H3BP28 ENST00000566110.5 ENST00000561858.5 I3L1T0 ENST00000569127.1 H3BSZ3 Q99807 ENST00000321998.10 [Q99807-1] ENST00000544894.6 [Q99807-2] ENST00000568985.5 [Q99807-1] Q8NI45 Q49A71 H3BS11 ENST00000566049.5 ENST00000569312.5 H3BTN8 |
